Lymph node mass transport

Abstract

Immunology Cytokines are transported around the body via a network of lymph ducts and lymph nodes. Conduits within lymph nodes convey cytokines from the subcapsular sinus (SCS) into the deep parenchyma. From there, they discharge into high endothelial venules. In the SCS, sinus-lining cells prevent molecules greater than 70 kilodaltons from entering conduits. Nevertheless, Thierry et al. found that the massive 970-kilodalton pentamers of immunoglobulin M antibodies can cross into conduits. Transport is mediated by transient, activated, antigen-specific B cells, thus enabling rapid mobilization of the first wave of antibodies produced during an acute infection. J. Exp. Med. 215 , 2972 (2018).