Luteolin a dietary flavonoid attenuates isoproterenol-induced myocardial oxidative stress in rat myocardium: An in vivo study

Abstract

Aim of the present study, an attempt has been made in acute and chronic periods after isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Luteolin supplimentated by intragastric intubation at a daily dose of 0.3mg/kg body weight in acute and chronic periods following MI. In acute MI model, luteolin had been administered once per day to rat groups during 30 days. On 29th and 30th day, the rats of the acute MI control groups were administered 85mg/kg body weight, isoproterenol, intraperitoneally intravel of 24h. In chronic MI model, luteolin supplimentated of rat group during 30 days. On the 1st and 2nd days, the rats of the chronic MI control and luteolin treatment groups were administered ISO by the same way. The ISO-induced rats both in acute and chronic models showed decrease in the levels of heart phospholipids and increased levels of cholesterol, triglycerides, free fatty acids and phospholipids in serum and heart, and also significantly increase in the activities of cardiac marker enzymes like Troponin I and T, CK, CK-MB, LDH, AST and ALT. Oral treatment with luteolin at a daily dose of (0.3mg/kg body weight) in both acute and chronic models showed significantly decrease in the levels of heart and serum lipid metabolism products and significant decrease in the levels of marker enzymes. The study results revealed that luteolin ameliorates cardiac damage in ISO-induced myocardial infarction by maintaining lipids levels by its antilipidemic effects in isoproterenol-induced myocardial infarcted rats.