Abstract
The National Lung Cancer Screening Trial (NLST) demonstrated the use of low dose helical computed tomography (LDCT) scans for lung cancer screening. However, the NLST was implemented in urban hospitals and prior to the Lung CT Screening Reporting and Data System (Lung-RADS). In this retrospective cohort study, 774 eligible patients received LDCT screening using Lung-RADS criteria. Eighty-four patients (10.9%) had subsequent testing performed compared to 24.2% in the NLST study. Of those with subsequent testing, 21.4% were diagnosed with lung cancer compared to only 4.6% in the NLST study. Lung-RADS significantly reduced unnecessary testing while identifying higher rates of lung cancer compared to the NLST.
Highlights
Lung cancer is the leading cause of cancer-related mortality in the USA, accounting for one in four cancer-related mortalities [1]
Among St. Claire Healthcare (SCR) patients who had additional testing performed, the percentage of patients identified with lung cancer was approximately five times higher compared to the National Lung Cancer Screening Trial (NLST) population
This demonstrates that the application of Lung-RADS in the screening procedures resulted in fewer subsequent testing procedures despite the high rate of lung cancer identified compared to the NLST
Summary
Lung cancer is the leading cause of cancer-related mortality in the USA, accounting for one in four cancer-related mortalities [1]. Kentucky has the highest incidence of lung cancer in the country at 91.4 per 100,000 compared to the national rate of 58.3 per 100,000 [2]. Appalachian Kentucky counties have an even higher incidence rate of lung cancer, at 107.2 per 100,000. The National Lung Cancer Screening Trial (NLST) was a large, multicenter, randomized controlled trial that compared annual low dose helical computed tomography (LDCT) to chest X-ray in high-risk individuals as a tool for lung cancer screening [6,7]. The NLST demonstrated a statistically significant improvement in survival with annual LDCT in individuals who are high risk for lung cancer. The impact of LDCT screening in a region with high rates of lung cancer may be underrepresented
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
