Abstract
BackgroundBreast cancer may be classified into luminal A, luminal B, HER2+/ER-, basal-like and normal-like subtypes based on gene expression profiling or immunohistochemical (IHC) characteristics. The aim of our study is to show the molecular profile characteristic of breast cancer in the North African population of Morocco. This work showed preliminary results and correlations with clinicopathological and histological parameters. Three hundred and ninety primary breast carcinomas tumor tissues were immunostained for ER, PR, HER2, CK5/6, CK8/18 and Ki67 using paraffin tissue.MethodsWe reviewed 390 cases of breast cancer diagnosed on January 2008 to December 2011 at the Department of pathology, Hassan II teaching hospital, Fez, Morocco. Age, size tumor, metastatic profile, node involvement profile, histological type and immunohistochemical profile were studied.ResultsThe average age was 46 years; our patients were diagnosed late with a high average tumor size. Luminal B subtype was more prevalent (41.8%), followed by luminal A (30.5%), basal-like (13, 6%), Her2-overexpressing (9, 2%), and unclassified subtype (4.9%).ConclusionThis study showed that molecular classification and biological profile may be different according to geographical distribution, to encourage further studies to know the genomic profile of tumors and the environment.Virtual slidehttp://www.diagnosticpathology.diagnomx.eu/vs/1675272504826544
Highlights
Breast cancer may be classified into luminal A, luminal B, Epithelial human receptor 2 (HER2)+/estrogen receptor (ER), basal-like and normal-like subtypes based on gene expression profiling or immunohistochemical (IHC) characteristics
Breast cancers were classified according to the World Health Organization (WHO, 2003) [7] while histological grading and staging were performed according to Modified Bloom-Richardson classification [8] and American Joint Committee on Cancer (AJCC) [9], respectively
The study was achieved on 390 patients diagnosed with infiltrating breast cancer and managed at the Department of pathology in Hassan II University Hospital in Fez
Summary
Breast cancer may be classified into luminal A, luminal B, HER2+/ER-, basal-like and normal-like subtypes based on gene expression profiling or immunohistochemical (IHC) characteristics. Several studies used routinely panels of immunohistochemical markers to classify breast cancers into subtypes similar to those previously defined using gene expression analyses [6]. The recent study was realized by Prat et al [4] They defined several immunohistochemical subtypes: (luminal A, Luminal B, HER2- enriched, basal-like) and a normal breast-like group that show significant differences in incidence, survival and response to therapy. Tumors which were negative at immunohistochemical staining for all markers (ER, PR, Her, Her, and CK5/6) were considered unclassified subtype [4] According to this classification, we performed immunohistochemical staining for ER, PR, Her, Her, CK8/18, basal CK5/6 and KI67 in paraffin sections from blocks of breast cancer. The aim of the present study was to estimate the prevalence of breast cancer subtypes in patients of the north east region of Morocco, and to correlate between clinical and pathological characteristics
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