Abstract
<p dir="ltr"><b>OBJECTIVE</b></p><p dir="ltr">To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by prediabetes phenotype.</p><p dir="ltr"><b>RESEARCH DESIGN AND METHODS</b></p><p dir="ltr">We searched multiple databases until April 01, 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and IFG+IGT. Individual participant data were pooled from relevant trials and analyzed through random-effects models using the within-trial interactions approach.</p><p dir="ltr"><b>RESULTS</b></p><p dir="ltr">Four trials with 2,794 participants (mean age 51.6 years, 60.6% men) were included: 1,240 (44.4%), 796 (28.5%), and 758 (27.1%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio (95% CI) for diabetes incidence in i-IFG was 0.97 (0.66, 1.44), i-IGT was 0.65 (0.44, 0.96), and IFG+IGT was 0.51 (0.38, 0.68); Pinteraction=0.01.</p><p dir="ltr"><b>CONCLUSIONS</b></p><p dir="ltr">Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG.</p>
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