Abstract
Hypertension is one of the most important mortality risks in the world and is considered the leading cause of deaths associated with cardiovascular disease. In an attempt to improve the treatments and apply them to a large number of disorders, a propranolol hydrochloride (Prop) based medicine it was developed in our laboratory, employing a multiparticulate system which operates in a biphasic manner, one portion of immediate and other of modified release. This study aimed at developing and validating a suitable method to quantify this new version of the drug using UV spectrophotometry, following what is recommended in RE 899/2003. The results showed that the method employed was linear, accurate, precise and robust in the range of 0.8 to 96.0 μg mL -1 , which allows it for routine use in quality control laboratories.
Highlights
Hypertension is a major factor risk for overall mortality, affecting one in three adults of 25 years or more and with an overall prevalence of 22% in adults over 18 years
Complications related to cardiovascular diseases occur predominantly at the early morning hours, since the blood pressure is higher
In an attempt to obtain a more effective therapeutic system for the treatments of hypertension that exists in the pharmaceutical market and, considering the physiological changes of the circadian rhythm, a biphasic multiparticulate system it was developed in our laboratory containing the drug propranolol hydrochloride (Prop), composed of a fraction of immediate release and other of modified release
Summary
Hypertension is a major factor risk for overall mortality, affecting one in three adults of 25 years or more and with an overall prevalence of 22% in adults over 18 years. Complications related to cardiovascular diseases occur predominantly at the early morning hours, since the blood pressure is higher. In an attempt to obtain a more effective therapeutic system for the treatments of hypertension that exists in the pharmaceutical market and, considering the physiological changes of the circadian rhythm, a biphasic multiparticulate system it was developed in our laboratory containing the drug propranolol hydrochloride (Prop), composed of a fraction of immediate release and other of modified release. This system, directed to the treatment of hypertension, aims at minimizing pressure peaks that occur in the morning
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