Abstract
Background: There is a lack of information about peripheral blood eosinophil activity during allergen-induced late-phase airway inflammation in asthma. The aim of this study was to evaluate eosinophil chemotaxis, production of reactive oxygen species (ROS), degranulation, and apoptosis during allergen-induced late-phase airway inflammation in asthma patients. Methods: 30 patients with asthma (AA), 25 with rhinitis (AR) and 20 healthy subjects (HS) were examined. Peripheral blood was collected 24 h before and 7 h as well as 24 h after the bronchial allergen challenge. Peripheral blood eosinophil chemotaxis, production of ROS and apoptosis were estimated flow cytometrically and degranulation was analyzed by the levels of neurotoxin in serum. Results: Eosinophil chemotaxis (A), production of ROS (B), degranulation (C) and apoptosis (D) are presented in Figure 1 and Figure 2. Conclusions: During allergen-induced late-phase airway inflammation, eosinophils from patients with AA demonstrated further alterations in their activity, manifested by increased chemotaxis, production of ROS and degranulation as well as diminished apoptosis. Eosinophil activity before the allergen challenge Eosinophil activity after the allergen challenge
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