Abstract
One of the very puzzling aberrations that occurs in liver disease is the elevation of blood ammonia.<sup>1</sup>Though this is not a constant finding it is often seen in patients with liver failure, especially those suffering from cirrhosis who have had portasystemic vein shunt operations.<sup>2</sup>Here the ammonia level may rise to several times the normal value and is thought to be at least in part responsible for symptoms of hepatic coma. This has been documented both in the laboratory and clinically where tremors, lethargy, staggering gait, coma, and death have been caused by elevating the blood ammonia and where such symptoms may be ameliorated before the terminal stages by lowering it.<sup>1,3</sup> Of the several methods currently used to lower blood ammonia, one of great theoretical interest is the administration of arginine.<sup>4</sup>The amino acid plays an important role in the Krebs-Henseleit cycle in which ammonia
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
