Abstract
The central GABAergic system is associated with normal blood pressure regulation, but the role of GAGA receptors in genetic hypertension remains unclear. This study was conducted to investigate GABA A receptor binding in several brain regions of spontaneously hypertensive (SHR) rats during development of hypertension. GAGA A receptor binding was labeled with [ 35S]TBPS and was assessed by quantitative autoradiography with the aid of a computer-assisted image analysis system. Densities of GABA A receptor binding sites were significantly lower in all hypothalamic and amygdaloid nuclei evaluated in 4-week-old SHR rats, when compared with their age-matched normotensive Wistar-Kyoto rats. At 12 weeks of age, GABA A receptor binding remained significantly lower in the central amygdaloid nucleus and paraventricular hypothalamic nucleus of SHR rats. Collectively, the results suggest that GABA A receptors in these nuclei are likely to be involved in the initiation and maintenance of hypertension. In conclusion, this study supports a notion that downregulation of GABA A receptor binding occurs in the hypothalamus and amygdala of SHR rats and may play a role in genetic hypertension.
Published Version
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