Low-dose Aspirin does not Increase Pregnancy Rates and Uterine Artery Blood Flow Velocity in Male-factor Infertility Patients Undergoing Intracytoplasmic Sperm Injection

Abstract

Objective: To determine the effects of low-dose aspirin on uterine artery blood flow velocity and pregnancy rate in an unselected group of patients undergoing intracytoplasmic sperm injection (ICSI). Material(s) and Method(s): A total of 126 ICSI procedures were analyzed prospectively. Inclusion criteria allowed only first-trial couples with long-standing infertility caused by a male factor. Besides the exclusion of female factors, the patient population was unselected. The aspirin (+) (n = 66) group received 80 mg aspirin beginning on the first day of the gonadotropin stimulation, and the aspirin (-) (n = 60) group received no treatment. Result(s): Duration of stimulation, serum levels of estradiol on the hCG day; total medication dosage of gonadotropin; numbers of mature oocytes collected; numbers of embryos transferred, were not significantly different. Clinical pregnancy rates were 25.0% versus 26.5% in aspirin treated and untreated groups (P＞ 0.05). Uterine artery pulsatility index (P1) and resistant index (RI) values on the hCG day were 2.30±0.50 and 0.80±0.05 in aspirin treated group versus 2.20±0.48 and 0.80±0.11 in aspirin untreated group, respectively (P＞ 0.05). Conclusion(s): Low-dose aspirin (80 mg) appears to have no beneficial effect on uterine blood flow velocity and pregnancy rates in an unselected group of patients undergoing ICSI for male factors infertility.