Abstract
Micronutrient zinc plays a major role in influencing the periodontal conditions in Type 2 diabetes mellitus (T2DM) subjects. In the developed countries nearly 40% of the people are zinc deficient among the T2DM. Now it is estimated that nearly 2 billion subjects in the developing world may be zinc deficient. The periodontal diseases are highly prevalent and can affect up to 90% of the world wide population. Many chronic diseases have been associated with periodontal disease which results in adverse pregnancy outcomes, cardiovascular disease, stroke, pulmonary disease, and diabetes, but the causal relations have not been established. Zinc in human play an important role in cell mediated immunity and was also an antioxidant and anti-inflammatory agent. Zinc helps in the stabilization of lysosomal membranes. The increased acid phosphatase activity might be a result of destructive processes in alveolar bone in advanced stages of periodontal disease. In light of the available data, the study aimed to show how low serum zinc and increased level of lysosomal enzyme, acid phosphatase affect the subjects of Type 2 diabetes mellitus with periodontitis.
Highlights
Type 2 diabetes mellitus (T2DM) is one of the most challenging health concerns of the 21st century
With the available data, the present study aimed to study the relationship between serum zinc and acid phosphatase level in type 2 diabetes mellitus with periodontitis
The demographic characteristics within group I, group II (T2DM without periodontitis), group III (T2DM with periodontitis) and group IV (Non-DM with periodontitis) are shown in Table 1.There were no statistical differences in the mean of the systolic blood pressure, and diastolic blood pressure among the four groups
Summary
Type 2 diabetes mellitus (T2DM) is one of the most challenging health concerns of the 21st century. It is a chronic disease reaching epidemic levels in both developed and developing countries. According to International Diabetes Federation (IDF), Diabetes Atlas, sixth edition, the prevalence of T2DM is increasing at an alarming rate, affecting 382 million people worldwide in 2013 and this would rise to 592 million in 2035 [1]. The West Pacific Region is home to one quarter of the world’s population, and China has the largest patient population with diabetes as well as Pacific Islands countries with the highest prevalence rates. The incidence of periodontitis is rapidly increasing worldwide and is still a significant problem for many patients with T2DM [2]. The possible for the dietary components to modulate inflammatory processes are found to be a new approach in the management of T2DM [4]
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