Abstract
Mean platelet monoamine oxidase (MAO) activity in 26 consecutively-studied male marijuana smokers was significantly lower than in a comparable group of non-marijuana smoking males. In addition, the level of current marijuana use reported by the subjects was significantly and inversely correlated with MAO activity. No acute reduction in MAO activity was found in response to smoking a marijuana cigarette containing 15 mg of delta-9-THC. Significant in vitro inhibition of MAO activity by THC was detected only at THC concentrations above 10 −5M, approximately 100 times the peak plasma concentrations seen in vivo following smoking.
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