Abstract
In an artificial FET-cycle, a corpus luteum is absent and therefore the exogenous support by progestogens is key to pregnancy establishment. Dydrogesterone (DYD) is an oral, systemic alternative to vaginal progesterone for luteal phase support. Measurement of DYD and and its metabolite, 20α-Dihydrodydrogesterone (DHD), is only feasible by LC/MS. While oral DYD is widely used in fresh IVF cycles, circulating concentrations vs. successful treatment have never been explored. This study determines plasma concentrations of DYD and DHD, measured on day of ET in a programmed anovulatory FET cycle, and describes the association with the outcome.
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