Abstract
The aim of the study was to evaluate clinical and coagulatory effects of low-molecular-weight heparin-coated extracorporeal circulation (ECC) in coronary artery bypass grafting (CABG).
Highlights
In former studies on ischaemic preconditioning, adenosine was found to trigger this cardioprotective process
We could not demonstrate a cytoprotective upregulation of HSP60 after an obligatory period of ischaemia, cardioplegic arrest and reperfusion
These data contribute to the evidence that heat left ventricle and cardiac energy metabolism after prolonged stress mediates a beneficial effect on recovery of the neonatal cold cardioplegic ischaemia in rabbits
Summary
In former studies on ischaemic preconditioning, adenosine was found to trigger this cardioprotective process. We investigated the capacity of heat stress to improve myocardial tolerance and cardiac energy metabolism in the isolated perfused neonatal rabbit heart subjected to prolonged cold cardioplegic ischemia. The aim of the study was to evaluate the link between myocardial energy metabolism (high-energy phosphorylated compounds and intracellular pH), as measured using 31phosphorus nuclear magnetic resonance spectroscopy (31P-MRS) and myocardial tissue oxygen pressure (ptiO2) in isolated rabbit hearts subjected to 2 h of cold cardioplegic ischaemia and reperfusion. The aim of the study was to investigate the effects of cardiopulmonary bypass (CPB) on intestinal vascular endothelial and smooth muscle function in a canine model of heart failure. Children who undergo cardiac surgery with cardiopulmonary bypass (CPB) often suffer myocardial damage after the operation. It was of objective of this study to investigate clinical and laboratory risk factors for myocardial dysfunction (MD) in neonates after arterial switch operation for transposition of the great arteries
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