Abstract
We investigated the relationship between low lean mass (LLM) and lower urinary tract symptoms (LUTS) using the 2005–2006 National Health and Nutrition Examination Survey (NHANES) dataset. We enrolled 959 men with an average age of 52.08 ± 7.91 years and performed weighted multiple regression analysis to determine the independent relationship between exposure variables (LLM, alternate LLM) and outcomes variables (urinary hesitancy, incomplete emptying, urinary frequency, nocturia, daytime LUTS, clinical LUTS) after adjusting for confounding factors. The prevalence of urinary hesitancy (OR = 7.76, P < 0.0001), incomplete emptying (OR = 2.49, P = 0.0070), urinary frequency (OR = 3.28, P < 0.0001), daytime LUTS (OR = 3.88, P < 0.0001) and clinical LUTS (OR = 8.11, P < 0.0001) was significantly higher among men with LLM compared to men without LLM. Moreover, alternate LLM (ALLM) was positively associated with urinary hesitancy (OR = 17.97, P < 0.0001), incomplete emptying (OR = 4.68, P = 0.0003), daytime LUTS (OR = 2.47, P = 0.0136) and clinical LUTS (OR = 12.18, P < 0.0001). These findings demonstrate that both LLM and ALLM were associated with a higher risk of LUTS in men aged ≥ 40 years, which suggested that early management and treatment of lean mass loss may improve or alleviate LUTS.
Highlights
Lower urinary tract symptoms (LUTS) such as urinary hesitancy, incomplete emptying, urinary frequency and nocturia remained the most common urologic symptoms that significantly affect the quality of life of more than 90% of men aged 50 P < 80 years [1,2,3,4]
Adjusted for age, body mass index (BMI), race, education level, income, insurance, alcohol intake, diabetes, hypertension, smoking status, comorbidity index. In this cross-sectional study included 959 men aged ≥ 40 years old, we investigated the relationship between low lean mass (LLM) and LUTS using weighted multiple regression analysis based on the National Health and Nutrition Examination Survey (NHANES) dataset (2005–2006)
After adjusting for covariates such as age, BMI, race, education level, income, insurance, alcohol intake, diabetes, hypertension, smoking status and comorbidity index, the risk of urinary hesitancy, incomplete urine emptying, urinary frequency, daytime LUTS, and clinical LUTS was significantly higher among men with www.aging-us.com
Summary
Lower urinary tract symptoms (LUTS) such as urinary hesitancy, incomplete emptying, urinary frequency and nocturia remained the most common urologic symptoms that significantly affect the quality of life of more than 90% of men aged 50 P < 80 years [1,2,3,4]. In the United States, the annual expenditure for LUTS medications is nearly 194 million dollars and represents a significant economic and public health burden [5, 6]. There is an urgent need to identify risk factors associated with LUTS. Low lean mass (LLM) is a key clinical indicator of muscle mass, strength and function [7]. The Foundation for the National Institutes of Health (FNIH) Sarcopenia www.aging-us.com project data demonstrated that LLM could be used to define sarcopenia, a skeletal muscle disorder that involves age-dependent decline in muscle mass and functional capacity [8]. Several other studies have shown that LLM could serve as a underlying risk factor for muscle weakness, disability and mortality in the elderly population [9,10,11,12]
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