Abstract
Supratentorial primitive neuroectodermal tumors (sPNET) are rarely occurred in adults. Only 39 cases have been reported in the past decade. The transformation from low grade to aggressive astrocytoma is well known. However, such convert from a low-grade astrocytoma (LGA) into a sPNET between two completely different tumors is rarer. This report discussed a 36-year-old male, who presented with the chief complaint of partial seizures and left limbs dysfunction and Magnetic resonance imaging (MRI) of whom revealed right frontal lesions which was operated to resect accompanied by the histological diagnosis of sPNET. The patient underwent operation 2.5 years ago because of seizures and was diagnosed with right frontal astrocytoma confirmed by pathology. However, radiotherapy was not preformed on him after the primary surgery. Histology now revealed high grade PNET. It is exactly uncertain that reports revelant to transformation from low-grade astrocytoma to a new kind of tumor or neoplasm induced by radiotation have been published. This case report is accompanied by a review of 39 cases of adult sPNET in the past decade, especially discussing about the transformation of low grade glioma into sPNET.
Highlights
Supratentorial primitive neuroectodermal tumors are rarely occurred in adults
It is exactly uncertain that reports revelant to transformation from low-grade astrocytoma to a new kind of tumor or neoplasm induced by radiotation have been published
This case report is accompanied by a review of 39 cases of adult Supratentorial primitive neuroectodermal tumors (sPNET) in the past decade, especially discussing about the transformation of low grade glioma into sPNET
Summary
This case is exactly uncertain that reports revelant to transformation from low-grade astrocytoma to a new kind of tumor or neoplasm induced by radiotation have been published. It is not clear whether the occurrence of sPNET in our patient represent transformation or de novo tumors, radiotherapy was not preformed on the patient after the primary surgery. This paper is accompanied by a review of 40 cases of adult sPNET in the past decade, for all patients, the estimated OS rates were 63.6 % at 1 year, 21.2 % at 2 years, 12.1 % at 3 years, and 6.1 % at 5 years. Abbreviations CNS, Central nervous system; LGA, low-grade astrocytoma; MRI, magnetic resonance image; OS, overall survival; sPNET, Supratentorial primitive neuroectodermal tumor
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