Abstract
The renal vascular effects of prostaglandin E2 (PGE2), 6-keto-PGE1, and PGI2 were investigated in indomethacin-pretreated rats. These prostanoids were infused directly into the left renal artery at rates ranging from 0.01 to 1.0 microgram/min, while renal blood flow and mean arterial blood pressure were constantly monitored. PGE2, 6-keto-PGE1, and PGI2 produced reductions in mean arterial blood pressure with threshold doses of 1.0, 0.3, and 0.03 microgram/min (P less than 0.01), respectively, and maximal vasodepressor responses of 18.9 +/- 4.3, 37.0 +/- 7.8, and 58.7 +/- 8.2 mm Hg (P less than 0.01), respectively. In addition, all three prostanoids caused a dose-related reduction in renal vascular resistance with a threshold dose of 0.01 microgram/min (P less than 0.05). The maximal reductions in renal vascular resistance were 2.59 +/- 0.52, 4.41 +/- 1.20, and 5.29 +/- 1.06 mm Hg/(ml per min) for PGE2, 6-keto-PGE1, and PGI2 (P less than 0.01), respectively. Whereas PGE2 an 6-keto-PGE1 produced dose-dependent increases in renal blood flow (maximal increases of 1.5 +/- 0.3 and 1.0 +/- 0.3 ml/min, respectively (P less than 0.01), PGI2 nonsignificantly increased renal blood flow at low doses and decreased renal blood flow at higher infusion rates (P less than 0.01). These data indicate that the in vivo rat kidney, similar to the kidneys of other species, is vasodilated by low doses of PGE2, PGI2, and 6-keto-PGE1.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.