Abstract
Objective: To investigate the relationship between low birthweight (LBW) and blood pressure and to assess whether LBW leads to a higher risk of high blood pressure (HBP) by gender in Chinese students aged 6–18 years. Also, to investigate whether the association was affected by childhood obesity. Methods: Data was obtained from a baseline dataset of a national school-based program. Anthropometric parameters, including height, weight, and blood pressure, were measured, while birthweight and other characteristics were obtained from questionnaires. Stratified chi-squared tests were used to compare the prevalence of HBP between LBW and normal birthweight (NBW) groups in each age and sex category. Multivariable logistic regressions were conducted to estimate the HBP risks in each birthweight group. Results: Both systolic and diastolic blood pressure showed a U-shaped relationship with increased birthweight. Compared to NBW groups, LBW girls showed a higher HBP risk, with an odds ratio of 1.29 (95% confidence interval (CI): 1.02, 1.64, p = 0.033), regardless of their current body mass index status, while no significant association in boys was found. Conclusions: Low birthweight is associated with higher HBP risk in adolescent girls, regardless of their childhood BMI status.
Highlights
Hypertension, or high blood pressure (HBP), is one of the largest contributors to cardiovascular disease disability-adjusted life-years (DALYs) [1]
Using baseline data from a national school program in China, the present study aimed to evaluate the relationship of low birthweight (LBW) with blood pressure and assess whether LBW leads to a higher HBP risk by gender in Chinese students aged 6–18 years
HBP in childhood people to hypertension in adulthood it isThus, associated with an increased risk predisposes of an early set of cardiovascular disease and mortality associated with an increased risk of an early set of cardiovascular disease and mortality
Summary
Hypertension, or high blood pressure (HBP), is one of the largest contributors to cardiovascular disease disability-adjusted life-years (DALYs) [1]. In China, 6.4% of school-aged children have HBP, and a considerable proportion of these children will develop hypertension in adulthood [2,3]. Previous studies indicate that low birthweight (LBW), defined as a birthweight less than 2500 g, is an important indicator of intrauterine growth status and a predictor of adverse health outcomes, such as hypertension and cardio-metabolic diseases throughout life [4,5,6,7]. The relationship between LWB and HBP remains unclear, and obesity during school-age is seldom brought into consideration
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