Low abundance of Akkermansia muciniphila and low consumption of polyphenols associated with metabolic disorders in child population

Abstract

A polyphenol-rich diet modulates the abundance of Akkermansia muciniphila ( A. muciniphila ), protecting against metabolic disorders caused by several pathologies such as obesity. The aim of this study was to determine if the polyphenol intake and the A. muciniphila abundance are related to metabolic disorders in Mexican children aged from 6 to 12 years old. To determine if the polyphenol intake and the relative abundance (RA) of A. muciniphila to relate to the presence of metabolic disorders in the child population, we performed a Cross-sectional study of 1190 children between 6 and 12 years of age, all of them with complete information of anthropometry, biochemical parameters and RA of A. muciniphila . The polyphenol intake was assessed through a food consumption frequency questionnaire. The findings showed a positive association between low RA of A. muciniphila with triglycerides 6.89 mg/dL (95%CI 0.5, 14.2) and negative with high-density lipoproteins (HDL) −1.35 mg/dL (95%CI -3.4, −0.6). The low intake of anthocyanins and flavan-3-ols are positively associated with triglycerides, 7.35 mg/dL (95%CI 1.80, 12.89) and 5.66 mg/dL (95%CI 0.013, 11.32), respectively. Conclusion: The low RA of A. muciniphila and less intake of polyphenols are directly associated to lipid disorders in child. • Less intake of polyphenols is directly associated to the metabolic disorders. • Low RA of A. Muciniphila is directly associated to the metabolic disorders. • Low RA of A. Muciniphila and less intake of polyphenols are related to lipid disorders. • In children. • Our results help to guide the implementation of strategies, interventions, or policies for metabolic disorders in child population.