Abstract
The aim of this study is to analyze a quality assurance program regarding the switch from loop electrosurgical excision procedure (LEEP) in general anesthesia (GA) to local anesthesia (LA) regarding patients' perioperative pain levels, patients´ satisfaction, as well as resection margins. We performed a single-center retrospective analysis of our quality assurance program including all patients undergoing LEEP at the Department of Obstetrics and Gynecology, Ordensklinikum Linz and Konventhospital Barmherzige Brueder Linz, from January 2021 to June 2024. 435 patients were questioned postoperatively after being treated with LEEP in LA regarding the perioperative pain as measured by a numeric rating scale (NRS) and patients' satisfaction. Clinical data were collected from the patients' electronic chart to investigate further parameters. Mean perioperative pain levels were stated as 1.3 (1.9). Five perioperative complications were reported. In seven out of 435 cases (1.6%) an inpatient readmission or a revision surgery under GA had to be performed. A R0 resection rate of 81.4% could be achieved. In 9.7% and 8.3% a R1 resection rate was reported on the ectocervix and on the endocervix, respectively. 95.3% of patients would choose LEEP in LA as their preferred method of anesthesia for a possible subsequent surgical LEEP procedure. Our study showed that the implementation of LEEP in LA was successful at our department as a new standard of care, resulting in a high R0 resection status and a high level of patients' satisfaction. We encourage physicians and organizations to switch from GA to LA when performing LEEP for cervical dysplasia.
Highlights
Despite the availability of Human Papilloma Virus (HPV) vaccines, cervical intraepithelial neoplasia (CIN) is the most common pre-malignant lesion in women worldwide [1]
We report on a retrospective analysis of our quality assurance program reporting—to the best of our knowledge—the largest series of loop electrosurgical excision procedure (LEEP) in local anesthesia (LA) published in literature so far
Despite its widespread use in many countries worldwide, relatively few data are available on the perioperative outcomes of LEEP in LA and only one randomized study has been published assessing the mode of anesthesia for LEEP [10]
Summary
Despite the availability of Human Papilloma Virus (HPV) vaccines, cervical intraepithelial neoplasia (CIN) is the most common pre-malignant lesion in women worldwide [1]. The loop electrosurgical excision procedure (LEEP) is a frequently performed surgical procedure in the field of gynecology for treating high-grade CIN and early invasive cancers [2]. Missing exact numbers it is estimated that in Germany between 90,000 and 150,000 LEEP procedures are performed annually, as well as 6000 procedures in Austria [3–5]. Quality parameters for performing LEEP have been outlined in the 2020 S3 guideline “Prevention of cervical cancer”, endorsed by the German (DGGG) and Austrian (OEGGG) Societies of Gynecology and Obstetrics. These quality parameters include a free resection margin (R0) rate of at least 80%, and intra- and postoperative bleeding complications in less than 3% of LEEP procedures [6]
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