Abstract
We report a case of long-term survival with complete remission after hepatic arterial infusion chemotherapy (HAIC) for liver metastasis from gastric cancer. A 62-year-old man underwent radical distal gastrectomy with D2 lymphadenectomy for an advanced gastric cancer. Solitary liver metastasis in the S2/3 segment was detected 26 months after initial surgery. The patient underwent HAIC with systemic chemotherapy. Serum CEA levels rapidly decreased, and CT scan showed disappearance of the tumor with complete clinical response 8 months after HAIC. HAIC was performed 83 times in total, until the hepatic artery proper was adequately obstructed. No severe adverse effects were observed during HAIC treatment. The patient is still disease-free without further chemotherapy more than 12 years after HAIC. Our experience suggests that HAIC should be considered as a treatment option in patients with resectable liver metastasis from gastric cancer. However, further studies are needed to verify the validity of HAIC for resectable liver metastasis from gastric cancer.
Highlights
Gastric cancer is the fourth most common malignancy worldwide [1]
We report a case of complete remission for more than 12 years following hepatic arterial infusion chemotherapy (HAIC) in a patient with solitary metachronous liver metastasis from gastric cancer
Among initial recurrence sites after curative gastrectomy, the liver was reported to account for 15.8–33.1 % of cases [8,9,10]
Summary
Gastric cancer is the fourth most common malignancy worldwide [1]. the prognosis of gastric cancer has significantly improved because of improvements in disease diagnosis and treatment, the prognosis of recurrent gastric cancer remains poor [2]. We report a case of complete remission for more than 12 years following hepatic arterial infusion chemotherapy (HAIC) in a patient with solitary metachronous liver metastasis from gastric cancer. After HAIC, CEA levels decreased rapidly and CT scan showed disappearance of the tumor with atrophic change of the left lobe, with a complete clinical response being obtained in March 2003 (8 months after commencement of HAIC) (Fig. 4).
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