Abstract
To evaluate the outcomes of initial trabeculectomy in granulomatous and non-granulomatous uveitis. Retrospective comparative study of 68 eyes that underwent an initial trabeculectomy. The mean follow-up was 74.18 and 74.86months in both groups (p=0.95). The intraocular pressure decreased from 40.03mmHg (±7.2) and 36.48mmHg (±11.3) to 14.00mmHg (±6.2) and 13.48mmHg (±5.7), the number of medications decreased from 3.73 (±0.7) and 3.58 (±0.9) to 1.00 (±1.4) and 1.13 (±1.4) on the last follow-up (p<0.01) in the granulomatous and non-granulomatous groups, respectively. More eyes in the granulomatous uveitis group developed delayed postoperative complications like cataract, transient hypotony and glaucoma progression. Success rates were 64.9 and 71.0%, while failure rates were 35.1 and 29.0% in both groups (p=0.84). Trabeculectomy seems to have comparable IOP control and survival in granulomatous and non-granulomatous uveitis. Nevertheless, more eyes in the granulomatous uveitis group developed late-onset complications.
Highlights
Uveitic glaucoma is a common and potentially vision threatening complication of uveitis.[1]
The intraocular pressure decreased from 40.03 mmHg (± 7.2) and 36.48 mmHg (± 11.3) to 14.00 mmHg (± 6.2) and 13.48 mmHg (± 5.7), the number of medications decreased from 3.73 (± 0.7) and 3.58 (± 0.9) to 1.00 (± 1.4) and 1.13 (± 1.4) on the last follow-up (p < 0.01) in the granulomatous and non-granulomatous groups, respectively
Granulomatous uveitis carries a greater risk of developing uveitic glaucoma 8, and there is need for glaucoma surgery compared with non-granulomatous uveitis.[9]
Summary
Uveitic glaucoma is a common and potentially vision threatening complication of uveitis.[1]. Several studies reported a favorable outcome of Mitomycin C (MMC) enhanced trabeculectomy in uveitic glaucoma, but few have looked at the outcome in glaucoma associated with major uveitis entities such as granulomatous and non-granulomatous uveitis.[10,11,12,13,14,15] the aim of our study was to evaluate the outcomes of MMC enhanced trabeculectomy as a first procedure in patients with glaucoma associated with granulomatous and non-granulomatous uveitis
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