Abstract
Electrical stimulation of nerves has become an established method in long-term treatment of patients with disturbances in the central or peripheral nervous system. This type of treatment raises questions as to the long-term consequences of implantation in terms of tissue and electrode reactions. The aim of the present study was to find out whether the structure of peripheral nerve tissue is altered after long-term contact with platinum electrodes and the way in which platinum electrodes are changed by prolonged implantation. The study was performed in six dogs which had undergone experiments in which stimulation electrodes were placed bilaterally on the carotid sinus nerves. Fibrotic changes in the nerve bundle and the perineurium were observed after 12·5 years. Accumulation of organic material on the electrode surface was revealed by Auger electron spectroscopy. The surfaces of the implanted electrodes had oxidised and had a high concentration of carbon and measurable amounts of sulphur, indicating corrosion.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
