Abstract
BackgroundThis study investigated the relationship between long-term body weight gain after maturity and the incidence of chronic kidney disease (CKD).MethodsThe participants were 303 men without a history of cardiovascular and cerebrovascular diseases, kidney dysfunction, or dialysis treatment. Their body weight gain after maturity was examined using a standardized self-administered questionnaire. The participants were divided into two groups based on the presence/absence of a body weight gain of ≥10 kg since 20 years of age.ResultsAfter a 6-year follow-up, the cumulative incidence of CKD was significantly higher in participants with a body weight gain of ≥10 kg than in participants without body weight a body weight gain of ≥10 kg since 20 years of age (log-rank test: P = 0.041). After adjusting for the age, body mass index, estimated glomerular filtration rate levels, smoking and drinking habits, and the presence of hypertension, dyslipidemia, and hyperglycemia at baseline, the normal body weight participants with a body weight gain of ≥10 kg since 20 years of age was significantly related to the incidence of CKD (hazard ratio 2.47; 95% confidence of interval, 1.02–6.01, P = 0.045).ConclusionsThese results suggest that long-term body weight gain after maturity in normal body weight participants may be associated with the incidence of CKD, independent of current body weight.
Highlights
It is well known that the chronic kidney disease (CKD) is a risk factor for the progression of end-stage renal disease (ESRD) and cardiovascular morbidity and mortality.[1,2] At present, the large number of ESRD patients is thought to be associated with the increasing number of patients with CKD
In our previous study,[9] we found that hypertension and hyperglycemia alone and in combination were associated with the progression of CKD
The long-term body weight gain after maturity has been related to the progression of type 2 diabetes mellitus (DM), metabolic syndrome, cardiovascular disease (CVD), and cardiovascular mortality, independent of current body weight.[10,11,12,13,14,15]
Summary
It is well known that the chronic kidney disease (CKD) is a risk factor for the progression of end-stage renal disease (ESRD) and cardiovascular morbidity and mortality.[1,2] At present, the large number of ESRD patients is thought to be associated with the increasing number of patients with CKD. The long-term body weight gain after maturity has been related to the progression of type 2 DM, metabolic syndrome, cardiovascular disease (CVD), and cardiovascular mortality, independent of current body weight.[10,11,12,13,14,15] at present, the influence of the long-term body weight gain after maturity on the development of CKD has not been clarified, despite the fact that the long-term body weight gain after maturity has been associated with the progression of type 2 DM, metabolic syndrome, CVD, and cardiovascular mortality.[10,11,12,13,14,15]. This study investigated the relationship between long-term body weight gain after maturity and the incidence of chronic kidney disease (CKD)
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