Abstract
Recent experimental evidence shows that the π orbitals along the stacking of base pairs can facilitate the long-range charge transfer in DNA [J. Am. Chem. Soc. 120 (1998) 12950; Chem. Biol. 6 (1999) 85; Nature 382 (1996) 731]. Proton motion in the base pair hydrogen bonds has also been found to affect the transfer rate. To explain this behavior we propose a model considering interactions of doped charges with hydrogen bonds and vibrations in DNA. The charge trapped by either protons or vibrations can cause structural distortions leading to polaron formation. By further considering polaron diffusion in DNA we find that the charge transfer rate derived from the diffusion coefficient is in good agreement with the experimental results in poly(A)–poly(T) DNA (ko∼1010 s−1) [J. Am. Chem. Soc. 126 (2004) 1125].
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
