Abstract
22 asthmatic children and adolescents (10.5 ± 2.55 years) participated of three visits (2 months a part). On each visit spirometry, fractional exhaled nitric oxide (FeNO), level of asthma control (Asthma control test-ACT), and asthma severity were assessed. The beclomethasone (Clenil® 250 μg/jato-Laboratory Chiesi-Brazil), at a dose of 1 jet 12/12 h, started on the first visit.
Highlights
Recent guidelines focus on asthma control, a significant number of patients remains poorly controlled
One patient was classified as having controlled asthma, partially controlled asthma (PCA), and uncontrolled asthma (UC)
fractional exhaled nitric oxide (FeNO) levels, FEV1 (%), FEV1/CVF (%), and asthma control test (ACT) scores did not differ between atopic and non-atopic subgroups in 3 time points
Summary
Recent guidelines focus on asthma control, a significant number of patients remains poorly controlled. Asthma is a heterogeneous disease characterized by chronic inflammation of the airways, defined by history of respiratory symptoms of wheezing, breathlessness, chest tightness and coughing, along with chronic airflow limitation [1]. This disease presents different phenotypes [2] which may be related to the natural history of the disease, with immune, inflammatory and structural characteristics of the airways and clinical control. The inflammation, structural changes caused by the maintenance of the inflammatory process and the imbalance between extracellular matrix synthesis and degradation lead to reduction in airway caliber and bronchial hyperresponsiveness [1].
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