Abstract
IntroductionThe prognostic impact of QT interval prolongation has not been well studied in healthy Asians. We investigated the association between the QT interval with mortality and cardiovascular events in a healthy Southeast Asian population.MethodsThe QT interval corrected for heart rate using the Bazett’s formula (QTc) was measured in 2536 (825 men, mean age 65.7±7.5 years) Singaporean adults free of cardiovascular disease in the population-based Singapore Longitudinal Ageing Study. Outcomes were all-cause mortality and incident cardiovascular events (cardiovascular mortality, myocardial infarction (MI) and/or stroke).ResultsOver a mean 7.78 years (19695 person-years) of follow-up, there were 202 deaths (45 from cardiovascular causes), 62 cases of myocardial infarction and 64 cases of stroke. Adjusting for age, sex, and cardiovascular risk factors, QTcB prolongation remained independently associated with increased all-cause mortality (HR(per standard deviation) 1.27 (1.10–1.48), p = 0.0015), as well as increased risk of cardiovascular events (HR 1.20 (1.01–1.43), p = 0.0415) and MI/stroke (HR 1.22 (1.01–1.47), p = 0.0455), but not cardiovascular mortality alone (HR 1.05 (0.77–1.44), p = 0.7562).ConclusionsWe provide the first community-based estimates of the independent association of QT prolongation with all-cause mortality and cardiovascular events in Southeast Asians.
Highlights
ObjectivesGiven the presence of ethnic differences among some non-Asian ethnicities and lack of longitudinal population-based data among Asians, we aimed to study the association between the QT interval and both mortality and cardiovascular outcomes in our communitybased cohort of Southeast Asian adults without prior cardiovascular disease
The prognostic impact of QT interval prolongation has not been well studied in healthy Asians
Adjusting for age, sex, and cardiovascular risk factors, QTcB prolongation remained independently associated with increased all-cause mortality (HR(per standard deviation) 1.27 (1.10–1.48), p = 0.0015), as well as increased risk of cardiovascular events (HR 1.20 (1.01–1.43), p = 0.0415) and myocardial infarction (MI)/stroke (HR 1.22 (1.01–1.47), p = 0.0455), but not cardiovascular mortality alone (HR 1.05 (0.77–1.44), p = 0.7562)
Summary
Given the presence of ethnic differences among some non-Asian ethnicities and lack of longitudinal population-based data among Asians, we aimed to study the association between the QT interval and both mortality and cardiovascular outcomes in our communitybased cohort of Southeast Asian adults without prior cardiovascular disease
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