Longitudinal assessment of local and global functional connectivity following sports-related concussion

Abstract

Growing evidence suggests that sports-related concussions (SRC) may lead to acute changes in intrinsic functional connectivity, although most studies to date have been cross-sectional in nature with relatively modest sample sizes. We longitudinally assessed changes in local and global resting state functional connectivity using metrics that do not require a priori seed or network selection (regional homogeneity; ReHo and global brain connectivity; GBC, respectively). A large sample of collegiate athletes (N=43) was assessed approximately one day (1.74days post-injury, N=34), one week (8.44days, N=34), and one month post-concussion (32.47days, N=30). Healthy contact sport-athletes served as controls (N=51). Concussed athletes showed improvement in mood symptoms at each time point (p's<0.05), but had significantly higher mood scores than healthy athletes at every time point (p's<0.05). In contrast, self-reported symptoms and cognitive deficits improved over time following concussion (p's<0.001), returning to healthy levels by one week post-concussion. ReHo in sensorimotor, visual, and temporal cortices increased over time post-concussion, and was greatest at one month post-injury. Conversely, ReHo in the frontal cortex decreased over time following SRC, with the greatest decrease evident at one month post-concussion. Differences in ReHo relative to healthy athletes were primarily observed at one month post-concussion rather than the more acute time points. Contrary to our hypothesis, no significant cross-sectional or longitudinal differences in GBC were observed. These results are suggestive of a delayed onset of local connectivity changes following SRC.