Abstract
目的 研究不同诊断级别的慢性苯中毒者白细胞远期恢复水平与CYP2E1基因多态性的关系.方法对51名曾经住院治疗慢性苯中毒者(包括观察对象),按诊断级别分为3组,使用调查表和查看病历收集基本情况、外周血白细胞计数和CYP2E1基因多态性检测,比较3组间治疗前后白细胞数及目前白细胞数差异,应用多元回归分析探讨白细胞数远期恢复水平影响因素及与CYP2E1基因多态性的关系.结果慢性中重度组入院首次白细胞数低、接苯工龄短,与观察组和轻度组比较,差异有统计学意义(P＜0.05);3组间目前白细胞数的差异无统计学意义(P＞0.05);经多元逐步回归分析,入院首次白细胞数及CYP2E1 DraIDC(CC)基因型与目前白细胞数相关,有统计学意义(P＜0.01).结论慢性苯中毒者白细胞远期恢复与诊断级别无相关关系,CYP2E1 DraIDC(CC)基因型及接苯时间可能影响白细胞远期恢复。
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