Long-term renal prognosis of cardio-renal syndrome type 1

Abstract

Objectives To study the relation of acute kidney injury (AKI) and long-term chronic kidney disease (CKD) in patients with acute decompensated heart failure (ADHF). Methods The in-hospital and post-hospital clinical data of patients with ADHF were analyzed postoperatively. The AKI was diagnosed according to the KGIGO criteria, the estimated glomerular filtration rate was calculated based on serum creatinine value and the CKD was defined as an eGFR<60 mL·(min·1.73 m2)-1. Results Totally 318 patients were included. At 36 months after discharge, the decreased eGFR of 9.2% [95% confidential interval (CI) 5.9~13.0] in the AKI group was higher than the decreased eGFR of 3.8% (95% CI 1.15~5.52) in the non-AKI group. In multivariate Cox hazard ratio models, the hazard ratio (HR) of development of CKD stage was 3.012 (95% CI 1.917~4.305) in the patients with CKD at baseline, 1.849 (95% CI 1.205~2.395) in those without CKD at baseline and 1.975 (95% CI 1.213~2.435) in all the 318 patients. Conclusions The in-hospital AKI is an independent risk factor for long-term CKD development or progression, implicating the importance of long-term renal function in the patients with cardio-renal syndrome type 1. Key words: Kidney Diseases; Heart Failure; Syndrome; Prognosis