Year-end Sale % OFF 
Abstract
Serine has recently been shown to reduce oxidative stress and inflammation, which, when occurring in the hypothalamus, contribute to age-related obesity. To explore whether long-term serine administration reduces oxidative stress and body weight in aging mice, various concentrations of l-serine dissolved in water were administered to 18-month-old C57BL/6J mice for 6 months. The results showed that the administration of 0.5% (w/v) l-serine significantly reduced food intake and body weight gain during the experiment. Moreover, the administration of 0.5% l-serine decreased the concentrations of leptin, malondialdehyde, interleukin-1β, and interleukin-6, while it increased those of superoxide dismutase and glutathione, in both the serum and hypothalamus. Reactive oxygen species and the activity of nicotinamide adenine dinucleotide phosphate oxidase were reduced in the hypothalamus of aging mice treated with l-serine as compared with untreated control mice. Additionally, the expression of the leptin receptor increased while the levels of neuropeptide Y and agouti-related protein decreased in mice that had been treated with 0.5% l-serine. The expression of Sirt1 and phosphorylated signal transducers and activators of transcription 3 (pSTAT3) increased, while that of phosphorylated NFκB decreased in the mice treated with 0.5% l-serine. These results indicated that long-term l-serine administration reduces body weight by decreasing orexigenic peptide expression and reduces oxidative stress and inflammation during aging in mice, possibly by modulating the Sirt1/NFκB pathway. Thus, l-serine has the potential to be used in the prevention of age-related obesity.
Highlights
The hypothalamus is a critical part of the central nervous system that modulates the stress response and senses nutrient-related inputs
Our results further supported that long-term L-serine supplementation may alleviate age-related oxidative damage, since it is shown that L-serine increased the levels of antioxidant enzymes while decreasing those of ROS in the hypothalamus
The process of aging is associated with a redox imbalance and the accumulation of oxidative damage in many tissues, which is caused by an increase in ROS production and a decrease in antioxidant capacity [29]
Summary
The hypothalamus is a critical part of the central nervous system that modulates the stress response and senses nutrient-related inputs. In aging mice, increased levels of oxidative stress and inflammatory markers are observed in the hypothalamus [1,2,3]. L-Serine Supplementation in Aging Mice (ROS) [4,5,6] These elevations of oxidative damage and inflammatory responses in the central nervous system are believed to contribute to age-related diseases including obesity and various neurodegenerative disorders [7,8,9]. Sirt activity in the hypothalamus decreases in association with aging, and its low expression contributes to a low level of antioxidants and increased oxidative damage [10]. NFκB functions as a central regulator of the immune response and controls the secretion of inflammatory cytokines in many tissues including the hypothalamus [18,19,20]. NFκB is a central mediator of stress responses under conditions of oxidative stress and upon exposure to certain chemicals in the central nervous system [18]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
