Abstract
This study aimed to assess the suppressive effect of long-term diet supplementation with Lactobacillus strains on cognitive decline in the senescence-accelerated mouse prone 8 (SAMP8) model. For 43 weeks, fourteen-week-old female SAMP8 mice were fed a standard diet containing 0.05% (w/w) Lactobacillus casei subsp. casei 327 (L. 327) or Lactobacillus paracasei K71 (L. K71) derived from rice grains and sake lees, respectively. SAMP8 mice that were fed a L. K71-supplemented diet had better cognitive performance compared with the control and L. 327 groups in the Barnes maze and passive avoidance tests. An ELISA analysis revealed that the levels of serotonin were elevated in the serum and brain tissue of L. K71-fed mice. The protein expression levels of brain-derived neurotrophic factor (BDNF), cAMP response element binding protein (CREB), and phosphorylated CREB were evaluated using western blot. Long-term administration of L. K71 resulted in increased protein expression of BDNF and CREB phosphorylation in the hippocampus. These results suggest that prolonged intake of a diet supplemented with a Lactobacillus strain derived from sake lees may prevent age-dependent cognitive decline by upregulating BDNF expression in the hippocampus.
Highlights
Probiotics are defined as living microorganisms that confer health benefits on the host when administered in adequate amounts
We investigated whether long-term diet supplementation with Lactobacillus strains isolated from rice or sake lees could attenuate spatial learning deficits and memory loss in aged senescence-accelerated mouse prone 8 (SAMP8) mice
The cognitive performance of SAMP8 mice was assessed after 43 weeks of feeding with diets
Summary
Probiotics are defined as living microorganisms that confer health benefits on the host when administered in adequate amounts. Interest has been growing in the potential beneficial effects of dietary probiotics on behavior, mood, and mental health. Certain Lactobacillus and Bifidobacterium have been shown to improve gut health, as well as alleviate mood disorders and stress-induced behavioral changes. Administration of Lactobacillus helveticus NS8 in rats ameliorated behavioral (anxiety and depression) and cognitive dysfunction induced by chronic restraint stress [6]. Distrutti et al [7] showed that the age-related deficit in long-term potentiation was markedly attenuated in rats that received a mixture of eight different strains of bacteria. These findings suggest that daily intake of probiotics can improve cognitive functions
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