634- https://doi.org/10.1093/eurheartj/ehac031
Long COVID: post-acute sequelae of COVID-19 with a cardiovascular focus
Translate Article 
Emerging as a new epidemic, long COVID or post-acute sequelae of coronavirus disease 2019 (COVID-19), a condition characterized by the persistence of COVID-19 symptoms beyond 3 months, is anticipated to substantially alter the lives of millions of people globally. Cardiopulmonary symptoms including chest pain, shortness of breath, fatigue, and autonomic manifestations such as postural orthostatic tachycardia are common and associated with significant disability, heightened anxiety, and public awareness. A range of cardiovascular (CV) abnormalities has been reported among patients beyond the acute phase and include myocardial inflammation, myocardial infarction, right ventricular dysfunction, and arrhythmias. Pathophysiological mechanisms for delayed complications are still poorly understood, with a dissociation seen between ongoing symptoms and objective measures of cardiopulmonary health. COVID-19 is anticipated to alter the long-term trajectory of many chronic cardiac diseases which are abundant in those at risk of severe disease. In this review, we discuss the definition of long COVID and its epidemiology, with an emphasis on cardiopulmonary symptoms. We further review the pathophysiological mechanisms underlying acute and chronic CV injury, the range of post-acute CV sequelae, and impact of COVID-19 on multiorgan health. We propose a possible model for referral of post-COVID-19 patients to cardiac services and discuss future directions including research priorities and clinical trials that are currently underway to evaluate the efficacy of treatment strategies for long COVID and associated CV sequelae.
- Discussion
- 168
- 10.1016/j.pedn.2020.11.004
- Nov 11, 2020
- Journal of Pediatric Nursing
When Pandemics Collide: The Impact of COVID-19 on Childhood Obesity
- Research Article
- 18
- 10.1111/ajt.16368
- Nov 5, 2020
- American Journal of Transplantation
Management of lung transplantation in the COVID-19 era-An international survey.
- Supplementary Content
- 32
- 10.1053/j.ackd.2020.06.005
- Jun 23, 2020
- Advances in Chronic Kidney Disease
COVID-19 and Kidney Disease Disparities in the United States
- Research Article
- 34
- 10.1053/j.ackd.2020.07.004
- Jul 17, 2020
- Advances in Chronic Kidney Disease
COVID-19 in Kidney Transplantation: Outcomes, Immunosuppression Management, and Operational Challenges.
- Front Matter
- 4
- 10.1053/j.ajkd.2021.08.006
- Oct 7, 2021
- American Journal of Kidney Diseases
Understanding the Burden of the COVID-19 Pandemic for People With Kidney Disease
- Research Article
- 10.1016/j.jgo.2022.05.003
- May 17, 2022
- Journal of Geriatric Oncology
Inequity in inequity: Disproportional mortality risk in patients with cancer with COVID-19 in Brazil - a call to action
- Front Matter
- 10
- 10.1016/j.hlc.2021.09.008
- Sep 29, 2021
- Heart, Lung & Circulation
Cardiac Surgery in Australia During the COVID-19 Global Pandemic
- Peer Review Report
- 10.7554/elife.77562.sa1
- Mar 29, 2022
The overall mortality consequences of the COVID-19 pandemic in the United States are predominantly attributable to the direct impact of SARS-CoV-2 infection but there are substantial indirect effects among children and young adults, and in mortality from accidents, homicides, and overdoses.
- Peer Review Report
- 10.7554/elife.77562.sa0
- Mar 29, 2022
The overall mortality consequences of the COVID-19 pandemic in the United States are predominantly attributable to the direct impact of SARS-CoV-2 infection but there are substantial indirect effects among children and young adults, and in mortality from accidents, homicides, and overdoses.
- Front Matter
- 1
- 10.1016/j.jtho.2022.03.001
- Apr 21, 2022
- Journal of Thoracic Oncology
New Normal for Lung Cancer Clinical Trials Under Coronavirus Disease 2019
- Research Article
- 45
- 10.1161/strokeaha.120.029863
- Apr 30, 2020
- Stroke
emergent stroke team contact, and emergent initiation of EVT in eligible patients
- Research Article
- 34
- 10.1016/j.echo.2020.05.019
- May 20, 2020
- Journal of the American Society of Echocardiography
ASE Statement on the Reintroduction of Echocardiographic Services during the COVID-19 Pandemic
- Research Article
- 55
- 10.1111/ajt.16411
- Dec 16, 2020
- American Journal of Transplantation
Navigating the COVID-19 pandemic: Initial impacts and responses of the Organ Procurement and Transplantation Network in the United States.
- Research Article
- 29
- 10.1371/journal.pone.0269353
- Nov 14, 2022
- PLOS ONE
Although coronavirus disease 2019 (COVID-19) affects the respiratory system, it can also have neurological consequences leading to cognitive deficits such as memory problems. The aim of our study was to assess the impact of COVID-19 on working memory function. We developed and implemented an online anonymous survey with a working memory quiz incorporating aspects of gamification to engage participants. 5428 participants successfully completed the survey and memory quiz between 8th December 2020 and 5th July 2021 (68.6% non-COVID-19 and 31.4% COVID-19). Most participants (93.3%) completed the survey and memory quiz relatively rapidly (mean time of 8.84 minutes). Categorical regression was used to assess the contribution of COVID status, age, time post-COVID (number of months elapsed since having had COVID), symptoms, ongoing symptoms and gender, followed by non-parametric statistics. A principal component analysis explored the relationship between subjective ratings and objective memory scores. The objective memory scores were significantly correlated with participants' own assessment of their cognitive function. The factors significantly affecting memory scores were COVID status, age, time post-COVID and ongoing symptoms. Our main finding was a significant reduction in memory scores in all COVID groups (self-reported, positive-tested and hospitalized) compared to the non-COVID group. Memory scores for all COVID groups combined were significantly reduced compared to the non-COVID group in every age category 25 years and over, but not for the youngest age category (18-24 years old). We found that memory scores gradually increased over a period of 17 months post-COVID-19. However, those with ongoing COVID-19 symptoms continued to show a reduction in memory scores. Our findings demonstrate that COVID-19 negatively impacts working memory function, but only in adults aged 25 years and over. Moreover, our results suggest that working memory deficits with COVID-19 can recover over time, although impairments may persist in those with ongoing symptoms.
- Front Matter
- 8
- 10.1016/j.healun.2021.05.021
- Jun 9, 2021
- The Journal of Heart and Lung Transplantation
Covid-19 in recipients of heart and lung transplantation: Learning from experience
