Long chain carboxylic acids containing ether linkage: V. N‐methyl substituted glycine‐type amphoterics containing alkoxy radical

Abstract

AbstractThe substituted glycine‐type amphoteric surfactants containing long chain alkoxy and methylated amino groups, such as N‐(2‐alkoxyethyl)methylaminoacetic acids and (N‐[2‐alkoxyethyl]‐N‐[carboxymethyl] dimethylammonium) chlorides, or N‐(N‐[2‐alkoxyethyl]‐2‐aminoethyl) aminoacetic acids were synthesized, and their growth inhibitory activities against g positive, g negative bacilli, and some fungi were studied. The effect of substitution of methyl groups upon the amino group of the long chain alkoxyaminoacetic acids on their antimicrobial activities was examined, and the increasing effect, due to methyl substitution, was confirmed. The introduction of an aminoethyl radical between the alkoxyethyl and amino radicals of the substituted glycines also increased their antimicrobial activities. Dimethylsubstituted betain‐type amphoterics showed less antimicrobial activities than the corresponding glycinetype amphoterics. Moreover, aqueous solution of these substituted glycine‐type amphoteric compounds showed better surface activities at pH 4.0, 10.0 than at neutral pH.