Abstract
BackgroundLong-acting β2-adrenoceptor agonists have been shown to increase the risk of atrial arrhythmias in patients with stable chronic obstructive pulmonary disease. The aim of this study was to investigate whether perioperative long-acting β2-adrenoceptor agonists treatment would increase the risk of postoperative atrial arrhythmias after lung cancer surgery in chronic obstructive pulmonary disease patients.MethodsWe retrospectively analyzed 174 consecutive chronic obstructive pulmonary disease patients with non-small-cell lung cancer who underwent lobectomy or segmentectomy. The subjects were divided into those with or without perioperative long-acting β2-adrenoceptor agonists treatment. Postoperative cardiopulmonary complications were compared between the two groups.ResultsThere were no statistically significant differences between the perioperative long-acting β2-adrenoceptor agonists treatment group and the control group in the incidence of postoperative atrial arrhythmias (P = 0.629). In 134 propensity-score–matched pairs, including variables such as age, gender, comorbidities, smoking history, operation procedure, lung-cancer staging, and respiratory function, there were no significant differences between the two groups in the incidence of postoperative cardiopulmonary complications, including atrial arrhythmias.ConclusionsPerioperative administration of long-acting β2-adrenoceptor agonists might not increase the incidence of postoperative atrial arrhythmias after surgical resection for non-small-cell lung cancer in chronic obstructive pulmonary disease patients.
Highlights
Long-acting β2-adrenoceptor agonists have been shown to increase the risk of atrial arrhythmias in patients with stable chronic obstructive pulmonary disease
The aim of this study was to investigate whether perioperative β2-agonists treatment would increase the risk of postoperative atrial arrhythmias after pulmonary resection for non-small-cell lung cancer (NSCLC) in chronic obstructive pulmonary disease patients
174 patients (β2-agonists group: 71 and control group: 103, and incidence of atrial arrhythmias of the subjects β2-agonists group: 7 and control group: 8) in the present study were considered low power. In this retrospective observational study, the perioperative administration of β2-agonists did not increase the incidence of postoperative atrial arrhythmias (AF and Paroxysmal supraventricular tachycardia (PSVT)) after surgical resection for NSCLC in patients with Chronic obstructive pulmonary disease (COPD)
Summary
Long-acting β2-adrenoceptor agonists have been shown to increase the risk of atrial arrhythmias in patients with stable chronic obstructive pulmonary disease. The aim of this study was to investigate whether perioperative long-acting β2-adrenoceptor agonists treatment would increase the risk of postoperative atrial arrhythmias after lung cancer surgery in chronic obstructive pulmonary disease patients. The mainstay of pharmacological treatment in stable COPD are bronchodilators, such as long-acting β2-adrenoceptor agonists (β2-agonists) and long-acting muscarinic antagonists [2]. These bronchodilators have been shown to improve symptoms, quality-of-life, pulmonary function and mortality in patients with COPD. Postoperative atrial arrhythmias should be avoided in COPD patients with lung cancer who undergo surgical resection
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