Abstract
Secretory component (a glycoprotein) is an antigenically distinct portion of the secretory immunoglobulin A, which has been identified in a number of normal and neoplastic epithelial cells. Localization of secretory component was determined in pleomorphic adenomas of minor salivary gland origin using the four-step peroxidase-antiperoxidase technique. Antiserum that detected only free secretory component (FSC) was used. Staining for secretory component was noted in the epithelium that lined duct-like spaces; but was absent in myoepithelial cells and mucous acini. These findings suggest a role for FSC in evaluating the histogenesis of various salivary gland neoplasms.
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