Abstract
The present article describes the isolation of a new natural product of the lobophorin family, designated as lobophorin K (1), from cultures of the marine actinobacteria Streptomyces sp. M-207, previously isolated from the cold-water coral Lophelia pertusa collected at 1800 m depth during an expedition to the submarine Avilés Canyon. Its structure was determined using a combination of spectroscopic techniques, mainly ESI-TOF MS and 1D and 2D NMR. This new natural product displayed cytotoxic activity against two human tumor cell lines, such as pancreatic carcinoma (MiaPaca-2) and breast adenocarcinoma (MCF-7). Lobophorin K also displayed moderate and selective antibiotic activity against pathogenic Gram-positive bacteria such as Staphylococcus aureus.
Highlights
Lobophorins are natural products of marine origin with pharmacological interest due to their diverse biological activities
We have shown have shown that this new compound, lobophorin K, displays cytotoxic activities against two human that this new compound, lobophorin
The 16S rDNA of producing strain M‐207 was amplified by polymerase chain reaction (PCR)
Summary
Lobophorins are natural products of marine origin with pharmacological interest due to their diverse biological activities. They are members of the spirotetronate family first reported as anti-inflammatory compounds, such as lobophorins A and B [1]. Streptomyces species, are associated to corals and other invertebrates living up to 4700 m depth in the submarine Avilés Canyon [9,10,11]. Actinobacteria a wideup repertoire ofdepth chemically secondary metabolites with different antibiotic ordisplaying antitumor aactivities wide repertoire of chemically diverse secondary metabolites with different antibiotic or antitumor have been isolated from coral reef ecosystems from the Avilés Canyon [12]. K, obtained from Streptomyces isolated finding of cold‐water a new natural product, lobophorin. Selective antibiotic activity against pathogenic Gram-positive bacteria such as S. aureus
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