Abstract
Background and purposeIncreasing studies have shown that different kinds of lncRNAs play key role in the development of multiple carcinomas. Therefore, we conducted a meta-analysis to investigate an association between the expression level of lncRNAs and the prognosis of bladder cancer (death or other clinical outcomes). MethodsA systematic literature search was performed by using PubMed. Twenty-four studies were included in the meta-analysis based on the inclusion and exclusion criteria. In total, there are 1652 independent participants. ResultsThe result showed that high expression levels of lncRNAs were demonstrated to be associated with poor overall survival (OS) (HR = 2.33, 95%CI: 1.51–2.39, p < 0.01) in bladder carcinoma, but there was no significant correlation between lncRNAs level and recurrence-free survival (RFS) (pooled HR = 1.57, 95%CI 0.69–3.56, p = 0.284), and progression-free survival (PFS) (pooled HR = 1.37, 95%CI 0.79–2.38, p = 0.269). Additionally, increased lncRNAs expression was found to be moderately correlated with tumor stage and progression (II/III/IV vs. I, OR = 3.20, 95%CI: 1.72–5.98, p < 0.001). In addition, elevated lncRNAs expression predicted lymph node metastasis (LNM) significantly (pooled OR = 2.29, 95 % CI 1.33–3.95, p < 0.01). No significant heterogeneity was observed among studies except lymph node metastasis. ConclusionIn conclusion, high expression levels of lncRNAs were demonstrated to be associated with poor OS and positive LNM, and lncRNAs might be potential prognostic markers in bladder cancer.
Highlights
With the increasing incidence and mortality of cancer in China, it has become a major cause of death and public health problem all over the word
The result showed that high expression levels of lncRNAs were demonstrated to be associated with poor overall survival (OS) (HR 1⁄4 2.33, 95%CI: 1.51–2.39, p < 0.01) in bladder carcinoma, but there was no significant correlation between lncRNAs level and recurrence-free survival (RFS)
Increased lncRNAs expression was found to be moderately correlated with tumor stage and progression
Summary
With the increasing incidence and mortality of cancer in China, it has become a major cause of death and public health problem all over the word. The incidence and mortality of bladder cancer have been notably increased [3]. There are no specific symptoms for these patients who are at the early stage of bladder cancer, and most of the patients are at an advanced stage when they go to the hospital at the first time [4]. Since the prognosis of bladder cancer is closely related to the stage of disease at diagnosis, it is urgently needed to find out markers that more sensitive and specific for diagnosis at early stages [5]. We conducted a meta-analysis to investigate an association between the expression level of lncRNAs and the prognosis of bladder cancer (death or other clinical outcomes)
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