Abstract
lncRNA Mirt2 is a lipopolysaccharide- (LPS-) inducible inflammation inhibitor. We found that Mirt2 was downregulated in plasma of ulcerative colitis (UC) patients and the downregulation of Mirt2 distinguished UC patients from healthy controls. IL-22 was also downregulated in UC patients and positively correlated with Mirt2. Mirt2 overexpression led to upregulated, while Mirt2 siRNA silencing led to inhibited secretion of IL-22 from colonic epithelial cells treated with LPS. In addition, under LPS treatment, Mirt2 overexpression led to decreased, while Mirt2 siRNA silencing led to increased apoptotic rate of colonic epithelial cells. Therefore, Mirt2 is downregulated in ulcerative colitis and regulates IL-22 expression in colonic epithelial cells.
Highlights
In clinical practices, a common group of gastrointestinal disorders are inflammatory bowel diseases (IBD) [1]
Data showed that Mirt2 overexpression led to increased (Figure 3(b), p < 0:05), while Mirt2 siRNA silencing led to decreased secretion of IL-22 from HCnEpCs in medium (Figure 3(c), p < 0:05)
We found that Mirt2 was downregulated in Ulcerative colitis (UC) and Mirt2 may suppress the development of UC by positively regulating antiinflammatory IL-22
Summary
A common group of gastrointestinal disorders are inflammatory bowel diseases (IBD) [1]. It is clear that some inflammatory mediators, such as IL-23, TNF-α, and IL-12, participate in the pathogenesis of UC, and inhibition of the production and secretion of such mediators is considered to be beneficial for disease control and recovery [7, 8]. Another possible therapeutic approach is to increase the secretion of certain antiinflammatory cytokines, such as IL-22, which can inhibit intestinal inflammation [9].
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