Abstract
Long non-coding RNA (LncRNA) BRE-AS1 has recently proven to be a tumor suppressor in lung cancer. The present study aimed to investigate the involvement of lncRNA BRE-AS1 in prostate carcinoma (PC). In the present study we found that plasma BRE-AS1 and miR-145-5p were both down-regulated in PC patients than in healthy controls. Down-regulation of BRE-AS1 and miR-145-5p effectively distinguished early-stage PC patients from healthy controls. A significant and positive correlation between BRE-AS1 and miR-145–5p was only found in PC patients. BRE-AS1 overexpression mediated miR-145-5p up-regulation in PC cells, while miR-145-5p overexpression did not significantly affect BRE-AS1. Overexpression of BRE-AS1 and miR-145-5p led to inhibited proliferation and promoted apoptosis of PC cells. miR-145-5p inhibitor attenuated the effects of BRE-AS1 overexpression on cancer cell behaviors. Therefore, lncRNA BRE-AS1 may regulate cancer cell proliferation and apoptosis in PC by interacting with miR-145-5p.
Highlights
Prostate carcinoma (PC) as one of the most frequently diagnosed cancers amongst males is a major cause of cancer-related deaths [1]
A recent study proved the role of long non-coding RNA (lncRNA) BRE-AS1 as a tumor suppressor in lung cancer [10]
The key finding of the present study is that lncRNA BRE-AS1 is likely a tumor suppressor in PC and the actions of lncRNA BRE-AS1 in PC are likely mediated by miR-145-5p
Summary
Prostate carcinoma (PC) as one of the most frequently diagnosed cancers amongst males is a major cause of cancer-related deaths [1]. The molecular pathogenesis of PC is still largely unknown, leading to failures in clinical treatment [4]. The human genome transcribes both protein-coding mRNAs and non-coding RNAs (ncRNAs) [5]. Different from the functions of mRNAs as template of protein synthesis, ncRNAs participate both in physiological and pathological processes directly in the form of RNA [6,7]. According to the length and functionality, ncRNAs are divided into different subgroups, such as long ncRNAs (lncRNAs) and microRNAs (miRNAs), which are essential players in cancer biology [8,9]. LncRNA BRE-AS1 has recently proven as a tumor suppressor in lung cancer [10], while its role in other human diseases is unknown. We showed that lncRNA BRE-AS1 regulated cancer cell proliferation and apoptosis in PC possibly by interacting with miR-145-5p
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