Living with tardive dyskinesia: understanding the patient experience.

Tardive dyskinesia (TD) is an involuntary muscle movement typically caused by prolonged exposure to antipsychotic medications. Depending on the symptom severity and the affected body parts, it can cause a terrible decline in patients' daily activities and life quality. TD often persists despite discontinuation of the offending drugs. There was no approved or effective agent to treat the patients until valbenazine, a vesicular monoamine transporter-2inhibitor, became available. We report the case of a 64-year-old woman who started to take antipsychotics at the age of her late 20s for her schizophrenic symptoms and later developed left arm chorea-ballism in mid-50s. The patient's involuntary movements got progressively worse even after being freed from the medications and caused severe body weight loss due to difficulties in taking meals. Daily treatment with valbenazine gradually mitigated her symptoms, resulting in significant improvement in her feeding activities, body weight, and daily life quality. This is the first report, to our knowledge, describing the therapeutic potential of valbenazine to improve chorea-ballism associated with TD. Our observation highlights that valbenazine may relieve a broader spectrum of antipsychotic-induced involuntary movements.

Objective: This study aims to comparatively evaluate the quality of daily life and quality of work life among employees working in environments with different noise exposure levels to explore the potential impact of occupational noise on overall well-being. Methods: This cross-sectional study was conducted in the audiology department at Trakya University between April and July 2024. The study included 86 employees who worked in an industrial estate, street market, hospital laboratory, and office. Noise levels in the environments were measured with a sound level meter, and participants were asked to complete the Short-Form 12 Questionnaire (SF-12) and the Quality of Work Life (QWL). Results: Average noise levels were highest in the street market (73.63 dBA) and lowest in the office (55.80 dBA). A significant difference was found between laboratory employees and street market workers in the physical component of the SF-12 and between industrial estate workers and office employees in the mental component (P < .05). The QWL scores did not differ significantly by group. Regression analyses revealed that age significantly predicted Physical Component Score-12 scores, while both age and work environment were significant predictors of Mental Component Score-12; however, no predictors were associated with QWL. Conclusion: Even when below legal limits, noise exposure in various work environments has negative impacts on employees’ quality of daily life. It is important that occupational health and safety policies address not only loud noises but also common “noisy” working conditions. Regular noise measurements, encouraging the use of protective equipment, and awareness training could play a critical role in improving employees’ quality of daily and work life. Cite this article as: Avcı NB, Ali C, Nterntiman A, Ferat OM, Taşdemir Gürşen İ, Bulut E. Impact of varied noise exposure on workers’ quality of life and work: A multienvironment study. Arch Health Sci Res. 2026, 13, 0189, doi: 10.5152/ArcHealthSciRes.2026.25189.

Objective: to evaluate the efficacy of a comprehensive rehabilitation program on functional independence in daily life, exercise tolerance and quality of life (QoL) in patients with relapsing-remitting multiple sclerosis (RRMS) in remission.Material and methods. 38 patients with RRMS were analyzed (33 women and 5 men; age – 41.6±7.7 years; EDSS – 4.0 [3.5; 5.0] points, duration of MS – 8.0 [3.0; 21.0] years). The patients received comprehensive rehabilitation in a hospital for 2.5 weeks. The examination was carried out before and after the rehabilitation program. Independence in daily activities was assessed using the Functional Independence Scale, the Get Up and Go Test and the Berg Balance Scale. Exercise tolerance was determined using a cardiopulmonary exercise test (CPET) on a cycle ergometer. The following parameters were measured: oxygen consumption during exercise (VO2 peak oxygen uptake), percentage from the predicted VO2 peak (% pred VO2 peak) and maximal workload in metabolic units (MET). Walking speed was measured according to the Davis protocol in the SMART-D laboratory (Italy). QoL was determined using the SF-36 questionnaire, which assesses physical functioning (PF), general health (GH), vital activity (VT) and social functioning (SF). Cognitive functioning was assessed using the Montreal Cognitive Scale (MoCA) and depression using the Beck Depression Inventory (BDI). Results. After completion of the rehabilitation course, there was a significant increase in VO2 peak (from 18.8±3.8 to 20.4±4.3 ml/kg/min), % pred VO2 peak (from 59±13 to 63±14%), maximal workload (from 5.4±1.2 to 5.8±1.2 MET), maximal heart rate (from 140±14 to 147±13) and walking speed (from 0.84±0.29 to 0.97±0.28 m/s). At the same time, despite an improvement the patients did not reach the age- and gender adjusted reference values for exercise tolerance. QoL indicators also increased, reaching or exceeding the populational values obtained for the Russian population: PF – from 45 to 52.2; GH – from 51 to 52; VT – from 45 to 50; SF – from 62.5 to 75. The number of points on the BDI also decreased significantly (from 9 to 6), and the increase on the MoCA scale had tendency to significant difference (p=0.064). Conclusion. A comprehensive rehabilitation program in patients with RRMS in remission helps to increase exercise tolerance and improve functional independence and QoL.

BackgroundFibromyalgia is a disorder characterized by chronic widespread musculoskeletal pain, often accompanied by fatigue, cognitive disturbance, psychiatric symptoms, and multiple somatic symptoms. Various pharmacological and non-pharmacological therapies have been tried...

<p>The aim of this research is to analyze the role of daily stress, optimsm and self regulation toward the quality of life of type 2 individual with diabetic mellitus. The hypothesis of this research are: 1). There is a negative relationship between daily stress and quality of life; 2). Optimsm as moderate relation between daily stress and quality of life; 3). Autonom self regulation as moderate relation between daily stress and quality of life; 4). Controlled self regulation as mediator relation daily stress and quality of life. Research Methodology: The research is conducted among individuals who were diagnosed with type 2 diabetic mellitus in Sardjito Hospital Yogyakarta. There are 64 subjects who completed the research tools (daily stress, optimism, self regulation and quality of life scale) started from January 4th– February 12 2010. The research shows that there is a negative relation between daily stress and quality of life (r = 0,265; F = 22,304; p = 0,000; p < 0,01; significant). The result of moderate regression analysis shows optimsm is not moderate variable, but autonom self regulation is moderate variable (β = 0,004; p < 0,001; significant). The result of path analysis shows that controlled self regulation is mediator relation of daily stress and quality of life (p = 0,045; p < 0,05; significant). There is a negative significant relation between daily stress and quality of life. Optimism is not significant as moderate variable relation between daily stress and quality of life. Autonom regulation is significant as moderate relation between daily stress and quality of life. Controlled self regulation is significant as mediator relation of daily stress and quality of life.</p><p> </p>

Rationale & ObjectiveAlmost all dialysis patients experience polypharmacy but little is known about their experiences with medication or perceptions towards it. In this qualitative study, we aimed to gain insight into dialysis patients’ experiences with polypharmacy, the ways they integrate their medication into their daily lives, and the ways it affects their quality of life. Study DesignQualitative study using semi-structured interviews. Setting & ParticipantsDialysis patients from two Dutch university hospitals. Analytical ApproachInterviews were transcribed verbatim and analysed independently by two researchers through thematic content analysis. ResultsOverall, 28 participants were interviewed (29% women, mean age 63±16 years, median dialysis vintage 25.5 [IQR 15-48] months, mean daily number of medications 10±3). Important themes were (1) participants’ own definition of what constitutes ‘medication’, (2) their perception of medication, (3) medication routines and their impact on daily (quality of) life, and (4) interactions with healthcare professionals and others regarding medication. Participants generally perceived medication as burdensome but less so than dialysis. Medication was accepted as an essential precondition for their health even though participants did not always notice these health benefits directly. Medication routines and other coping mechanisms helped participants reduce the perceived negative effects of medication. In fact, medication increased freedom for some participants. Participants generally had constructive relationships with their physicians when discussing their medication. LimitationsResults are context dependent and might therefore not apply directly to other contexts. ConclusionsPolypharmacy negatively affected dialysis patients’ quality of life, but these effects were overshadowed by the burden of dialysis. The patients’ realization that medication is important to their health and effective coping strategies mitigated the negative impact of polypharmacy on their quality of life. Physicians and patients should work together continuously to evaluate the impact of treatments on health and other aspects of patients’ daily lives.

Gastroesophageal reflux disease (GERD) is a common disease encountered in daily medical care and clinical problem which hampers daily life and reduces quality of life (QOL). The coexistence of GERD-related symptoms with the typical GERD symptoms, such as heartburn or acid regurgitation, and various upper abdominal symptoms is frequently observed in patients with GERD. However, the effect of these coexisting symptoms on the daily life and QOL of patients with GERD has not been clarified. Therefore, the effects of the various upper abdominal symptoms coexisting with GERD on the daily life and QOL of such patients were compared. A total of 113 newly diagnosed patients who visited our hospital with typical GERD symptoms were assessed using the modified frequency scale for the symptoms of GERD (MFSSG), gastroesophageal reflux and dyspepsia therapeutic efficacy and satisfaction test (GERD-TEST), and short-form 8-item health survey (SF-8) questionnaires. The "gastroesophageal reflux symptom" (7 items) and "dyspepsia symptom" (7 items) groups were divided into two "typical symptoms" and two "atypical symptoms" for a total of four categories. The Pearson's correlation coefficient and multiple regression analysis were used to evaluate the correlations between each symptom category and dissatisfaction for daily life [eating, sleeping, daily activities, mood, as well as dissatisfaction for daily life-symptom subscale (SS), which is the average of the four items in the GERD-TEST, the physical component summary [PCS] and mental component summary [MCS] of the SF-8, and the influence of each symptom category on the daily life and QOL. The incidences of each symptom category in patients with GERD were high: typical GERD (100%), atypical GERD symptoms (67.3%), typical functional dyspepsia (FD) (71.7%), and atypical FD (75.2%). Pearson's correlation analysis demonstrated significant correlations between each symptom category and living status (dissatisfactions of eating, sleeping, daily activities, daily life-SS) and almost all items in SF-8 (PCS, MCS) (P < 0.05). Multiple regression analysis indicated the largest influences of each symptom category on living status and QOL in descending order: dissatisfaction for eating (atypical FD, typical FD), daily activities (atypical FD, typical FD, typical GERD), mood (atypical FD), daily life-SS (atypical FD, typical FD), PCS (typical FD), and MCS (atypical FD) (P < 0.05). Coexisting FD symptoms, particularly atypical FD symptoms, had a large influence on the impairments of daily life and decreases in QOL. Daily medical care of GERD requires attention to coexisting symptoms and their treatment instead of just focusing on the chief complaints by patients.

Lumbar spinal stenosis (LSS) can interfere with daily life and quality of life (QOL). Evaluating physical function and QOL and helping patients to improve is the focus of rehabilitation. Phase angle (PhA) assessment is widely used to measure body composition and is considered an indicator of physical function and QOL. This study investigated the relationship between PhA and physical function, physical activity, and QOL in patients with LSS. PhA, handgrip strength, walking speed, Timed Up and Go test (TUG), Life Space Assessment (LSA), Prognostic Nutritional Index (PNI), Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ), and EQ-5D were assessed and statistically analyzed. The study included 133 patients with LSS. Multiple regression analysis of PhA adjusted for age, sex, and body mass index (Model 1) and for Model 1 + PNI (Model 2) showed significant correlations (P < 0.05) with handgrip strength, walking speed, TUG, and LSA. Regarding QOL, PhA was significantly correlated (P < 0.05) with lumbar function in JOABPEQ. PhA was associated with physical function and QOL in patients with LSS and might be a new clinical indicator in this population.

Tardive Dyskinesia Induced by a Switch From Haloperidol Depot to Paliperidone Palmitate

Hemophilia A (HA) negatively impacts quality of life (QoL). Treatment with the bispecific antibody emicizumab has shown efficacy and safety in people with HA in clinical trials, but long-term QoL data are limited. To investigate the QoL of people with HA receiving emicizumab over 97 weeks in the prospective, observational TSUBASA study in Japan. Data were collected from participants aged ≥6 years with HA without factor VIII inhibitors and caregivers of participants of any age from November 2019 to October 2023. Quality of daily life was measured via the 36-Item Short Form Health Survey, the International Physical Activity Questionnaire, the Work Productivity and Activity Impairment Questionnaire and Classroom Impairment Questionnaire: Hemophilia Specific, and a survey-based questionnaire evaluating daily life, completed by the participant and their caregiver. Overall, 104 participants aged ≥6 years were enrolled. The median (range) age was 39.0 (6-73) years. Eighty-five (81.7%) participants had severe HA; 21 (20.2%) had target joints. The 36-Item Short Form Health Survey scores were mostly unchanged across the study period and comparable with Japanese national standard values. The proportion of participants engaging in high physical activity increased from 20.2% to 27.3% between baseline and week 97. The Work Productivity and Activity Impairment Questionnaire and Classroom Impairment Questionnaire: Hemophilia Specific scores were generally stable. The questionnaires showed improvements in activity, motivation for work/school, and bleed anxiety, as judged by participants and caregivers. QoL outcomes remained largely unchanged across the study period. Notable improvements were observed in physical activity levels, motivation for work/school, and anxiety related to bleeding, as reported by participants and caregivers.

Anxiety, Depression, and Quality of Life in Parkinson's Disease

TSUBASA Study: A Prospective Study Evaluating the Association between Physical Activity and Bleeding Events, Quality of Daily Life, and Safety in People with Hemophilia A without FVIII Inhibitors

The ability of therapeutic exercise after stroke to improve daily functioning and quality of life (QOL) remains controversial. We examined treatment effects on these outcomes in a randomized controlled trial (RCT) of exercise in subacute stroke survivors. This is a secondary analysis of a single-blind RCT of a 12-week program versus usual care. Baseline, post-treatment and 6-month post-treatment daily functioning and QOL were assessed by Barthel index, Functional Independence Measure, instrumental activities of daily living, Medical Outcomes Study short-form 36-item questionnaire (SF-36), and Stroke Impact Scale (SIS). Of 100 randomized subjects, 93 completed the postintervention assessment, (mean age 70; 54% male; 81% white; mean Orpington Prognostic Score 3.4), and 80 had 6-month post-treatment assessment. Immediately after intervention, the intervention group improved more than usual care in SF-36 social function (14.0 points; P=0.0051) and in SIS (strength [9.2 points; P=0.0003], emotion [5.6 points; P=0.0240], social participation [6.6 points; P=0.0488], and physical function [5.0 points; P=0.0145]). Treatment was marginally more effective on Barthel score (3.3 points; P=0.0510), SF-36 (physical function [6.8 points; P=0.0586], physical role function [14.4 points; P=0.0708]), and SIS upper extremity function (7.2 points; P=0.0790). Effects were diluted 6 months after treatment ended. This rehabilitation exercise program led to more rapid improvement in aspects of physical, social, and role function than usual care in persons with subacute stroke. Adherence interventions to promote continued exercise after treatment might be needed to continue benefit.

Background: Stroke affects brain function and causes personality, mood and emotional changes.There is a strong link between stroke, depression, and anxiety.One in three people experience depression at some point during the five years after their stroke.This study aimed to analyze the correlations of depression with daily life activity and quality of life among post-hemorrhagic stroke patients.Subjects and Methods: This was a cross sectional study conducted at Sultan Agung Hospital.A sample of 33 post-hemorrhagic stroke patients was selected for this study.The dependent variable was activity of daily living (ADL) and quality of life.The independent variable was depression.Depression was measured by Beck Depression Inventory (BDI).Quality of life was measured by SSQol.Activity of daily living was measured by Barthel Index.The data were analyzed by Pearson correlation.Results: Of 33 post-hemorrhagic stroke patients, 19 (57.6%) patients were 45 to 54 years of age.As many as 2 (6.1%) patients had depression, either mild or severe.The Beck Depression Inventory (BDI) score was mean= 24.4 and SD= 9.8.Stroke Specific Quality of Life Scale (SS-QOL) score was mean= 14.0 and SD 15.3.Depression was correlated with ADL (r= -0.86; p<0.001) and quality of life (r= -0.75; p<0.001).Conclusion: Depression is correlated with activity of daily living and quality of life among post-hemorrhagic stroke patients.

Physical activity in daily life and exercise capacity have not been assessed in patients with Crohn's disease to date. To evaluate the physical activity in daily life, exercise capacity, quality of life, and prevalence of mood disorders in patients with moderate-to-severe Crohn's disease on infliximab-induced remission and the possible associations among variables. A cross-sectional preliminary study was conducted. Twenty-six patients with Crohn's disease and 20 controls were selected. Participants underwent evaluation of physical activity in daily life (triaxial accelerometer), exercise capacity (shuttle walk test), handgrip strength, quality of life, and presence of mood disorders. The number of steps taken (7446±3081 vs 7898±2487), active time (80.6±42 vs 89.7±24.3min), shuttle walk test distance [665 (405) vs 710 (409) m] and handgrip strength [31 (15) vs 29 (20) kgf did not show any difference between the patients with Crohn's disease and the controls. The time spent lying down [95.8 (68.8) vs 60.9 (74.7) min] was greater and some domains of the quality of life were superior in the patients with Crohn's disease. No correlation was observed between the physical activity in daily life and quality of life or presence of mood disorders in patients with Crohn's disease. Patients with Crohn's disease on infliximab-induced remission, despite to more time spent lying down, they have the same level of physical activity in daily life and exercise capacity min compared with the controls.