Abstract

Objective To investigate the clinical efficacy of live combined bacillus subtilis and enterococcus faecium enteric-coated capsules combined with smecta in the treatment of antibiotics-related diarrhea. Methods 80 patients with antibiotics-related diarrhea were randomly divided into a study group and a control group. The study group was treated with live combined bacillus subtilis and enterococcus faecium enteric-coated capsules (two capsules each time, three times a day) and smecta (taking 3.0 g dissolved in 50 ml warm water between meals, three times a day) and the control group with live combined bacillus subtilis and enterococcus faecium enteric-coated capsules (two capsules each time, three times a day). The relief times of main symptoms (diarrhea, bloating, fatigue), stool frequency and forming time, mold detection rate, treatment effective rate, and adverse drug reactions were compared between these two groups. Results The effective rate was significantly higher in the study group than in the control group (χ2=4.021, P<0.05). After the treatment, the relief times of diarrhea, bloating, and fatigue and stool forming time were significantly shorter and the stool frequency and stool mold detection rate were significantly lower in the study group than in the control group (t=-15.460, t=-10.086, t=-6.555, P<0.01; t=-3.471, P< 0.01; t=-1.903, P<0.01; χ2=7.440, P<0.05). No serious adverse reactions occurred in both groups. Conclusions Live combined bacillus subtilis and enterococcus faecium enteric-coated capsules combined with smecta in the treatment of antibiotics-related diarrhea is effective, safe, and reliable, can rapidly improve the patients’ clinical symptoms, has no adverse drug reactions, and has clinical application value. Key words: Live combined bacillus subtilis and enterococcus faecium enteric-coated capsules; Smecta; Antibiotics-related diarrhea

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