Liquisolid Technique for Enhancement of Dissolution Properties of Lornoxicam

Abstract

Objective: Liquisolid technique is a new approach for delivery of drugs through oral route. This technique is suitable for poorly or water insoluble drugs and also for immediate or sustained release formulations. Design of this technique was according to new mathematical model proposed by Spireas et al. The in vitro dissolution property of slightly water soluble Lornoxicam was improved by exploring the potential of Liquisolid system (LS) using two non solvents. Material & Methods: Different LS compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to produce acceptably flowable and compressible admixture. Avicel PH 102, Aerosil 200 and Explotab, polyethylene glycol 400 and propylene glycol were employed as carrier, coating material, disintegrant and non volatile solvent respectively for preparing LS compacts. Evaluation: The in vitro release pattern of LS compacts and directly compressed tablets were studied using USP-II apparatus. The prepared LS compacts were evaluated for their flow properties such as bulk density, tapped density, angle of repose, Carr's compressibility index and Hausner's ratio. The interaction between drug and excipients in prepared LS compacts were studied IR spectroscopy. The drug release rates of LS compacts were distinctly higher as compared to directly compressed tablets, which show significant benefit of LS in increasing wetting properties and surface area of drug available for dissolution. The LS-1 of LS powder system showed acceptable flowability, Carr's compressibility index and Hausner's ratio. The DSC and XRD studies conforms the no significant interaction between the drug and excipients used in LS compacts. Conclusion: From this study it concludes that the LS technique is a promising alternative for improvement of dissolution property of water-insoluble drugs. © 2014 iGlobal Research and Publishing