Abstract
High-pressure liquid chromatography using reversed-phase and/or ion-pair techniques was used to optimize resolution of aspirin-containing muscle relaxant mixtures as well as other therapeutic agents commonly found in muscle relaxant-analgesic mixtures. The compounds were chromatographed on an octadecylsilane column using methanol-water solvent systems, some of which contained tetrabutylammonium cation as counterion. Mixtures of methocarbamol-aspirin and chlorzoxazone-acetaminophen were selected to demonstrate separation and quantification. The methocarbamol-aspirin mixture was chromatographed with methanol-water (40:60, pH 6.8) containing 0.01M tetrabutylammonium cation at a flow rate of 2.0ml/min. The chlorzoxazone-acetaminophen mixture was chromatographed with methanol-water (50:50) at a 2.0-ml/min flow rate. The separation and quantitation of each mixture were achieved in approximately 8min with accuracy in the 2–3% range.
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