Abstract
A sensitive and specific high-performance liquid chromatographic assay for the optical isomers of ibuprofen in plasma is reported. The isomers were converted to their diastereoisomeric S(+)-2-octyl esters and were resolved with two silica columns in series and a mobile phase containing 0.05% isopropyl alcohol in heptane. The lower limit of sensitivity was 0.5 μ/mL. The plasma concentrations of the optical isomers in a normal volunteer following administration of racemic, S(+)-, and R(—)-ibuprofen are reported. Following administration of R(—)-ibuprofen, there was stereoselective inversion of R(—)- to S(+)-ibuprofen.
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