Abstract
Objectives: Type 2 diabetic subjects (T2DM) tend to present atherogenic dyslipidemia (AD), characterized by high triglycerides, low HDL cholesterol (HDL-C) levels, and a preponderance of small LDL particles. Moreover, the number of LDL particles (LDL-P) has been suggested to be a better predictor of cardiovascular risk than LDL cholesterol (LDL-C) in patients with high cardiometabolic risk. We developed a novel advanced lipoprotein test (ALT) based on 2D diffusion-ordered 1H NMR spectroscopy (DOSY) to compare the lipid and lipoprotein profiles of T2DM subjects with and without AD.
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