Abstract
ObjectiveTo explore the association between lipoprotein-related phospholipase A2 (Lp-PLA2) and the risk of Parkinson’s disease (PD).MethodsA case-control study involving 58 hospitalized PD patients and 60 healthy controls was carried out. Serum Lp-PLA2 level was detected. According to the disease course and severity, PD patients were subdivided to analyze the clinical value of Lp-PLA2. Relationship between Lp-PLA2 and PD risk was analyzed by logistic regression. Diagnostic value of Lp-PLA2 in PD patients was investigated using receiver’s operator characteristic curves.ResultsLp-PLA2 level was significantly higher in the PD patients compared with the controls, and was significantly and positively correlated with the Hoehn-Yahr (H&Y) stage. The serum Lp-PLA2 level and H&Y stage of PD patients with a longer disease course were significantly higher than those with a shorter disease course. PD patients with milder conditions had significantly lower serum Lp-PLA2 levels than patients with severe conditions. Multivariable logistic regression analysis indicated higher Lp-PLA2 level was an independent risk factor of PD patients. Moreover, the area under the curve for Lp-PLA2 was 0.703, which was between those of homocysteine and serum amylase A.ConclusionTo our knowledge, this is the first study to show that increased level of Lp-PLA2 is associated with the risk of PD. Lp-PLA2 may be used for early detection of PD, and provides an effective intervention target for clinical treatment of PD.
Highlights
Parkinson’s disease (PD) is a common neurodegenerative disorder that occurs mostly in middleaged and elderly people
The results showed that the levels of cystatin C (Cys C), serum amylase A (SAA), HCY, and Lp-PLA2 in the PD group were significantly increased, while the levels of ALT, AST, BUN, TC, and low-density lipoproteins (LDLs) in this group were significantly lower than those in the control group,which remained significant after Bonferroni correction
We found that in addition to Lp-PLA2 level, the expression levels of Cys C, SAA, and HCY were higher in the PD patients than those of the control group
Summary
Parkinson’s disease (PD) is a common neurodegenerative disorder that occurs mostly in middleaged and elderly people. Lp-PLA2 Is a Risk Factor for Parkinson’s Disease (Sveinbjornsdottir, 2016). Many theories have attempted to explain the etiology of PD, the exact pathogenesis is not yet fully understood. In addition to the widely-studied pathological mechanisms of mitochondrial dysfunction (Bose and Beal, 2016), oxidative stress (Dias et al, 2013), and abnormal protein degradation (Ebrahimi-Fakhari et al, 2012), growing evidences from human samples and animal models show that inflammation plays a key role in the pathogenesis of PD (Dzamko et al, 2015; Caggiu et al, 2019; Chen et al, 2019)
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