Abstract
We have studied lipolytic-active esterases from the epididymal fat pads of mice with hereditary obesities caused by the mutant genes, diabetes (gene symbol, db), obese ( ob) and yellow ( A Y ). The A Y and ob alleles are maintained in the inbred strain C57BLJ6J, and the db allele is propagated in the related strain C57BL/KsJ. The effect of each mutation on lipolytic esterase activity was determined by comparing agarose gel zymograms of mutant with non-mutant normal mice. The A Y allele did not alter the isozyme pattern of at least five bands characteristically present in normal mice. Isozyme deletions occurred in diabetic mice of C57BL/KsJ- ob and obese mice of C57BL/6J- ob. These findings suggest that the pathogenesis of obesity caused by the A Y allele differs from that of the db and ob alleles; apparently, a major abnormality in db and ob concerns lipolysis.
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