Abstract
A 51-year-old man who was positive for the human immunodeficiency virus (HIV) and had been treated with a conventional protease-inhibitor–based antiretroviral regimen for four years had wasting of the fat of the extremities and face (especially of Bichat's fat pad), abnormal deposition of fat in the neck and trunk (“bull neck”; Panels A and B), insulin resistance, and hypertriglyceridemia. The complete blood count, the hepatic profile, and the levels of thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, and prolactin were normal. The results of a dexamethasone suppression test and the 24-hour urinary cortisol level were also normal. In a substantial proportion . . .
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