Lipid profile in hospitalized patients with COVID-19 depending on the outcome of its acute phase: data from the international registry "Dynamics analysis of comorbidities in SARS-CoV-2 infection survivors"

G P Arutyunov ,D A Schukarev,Sh N Musaelyan,A S Blagonravova,T S Fil,A S Galyavich,T P Kolchinskaya,R G Muradyan,A E Zheldybaeva,Z F Kim,V E Lisyanskaya,E Yu Ivanchenko,A G Arutyunov,R D Skvortsova,D R Shikhaliev,V A Kordyukova,I M Kuranova,N A Lyubavina,V A Pogrebetskaya,D A Platonov,K V Kuzmichev,E S Kim,N A Trostyanetskaya,N V Markov,S V Nedogoda,T V Kryukova,I V Shavrin,T V Lisun,Ya A Sidorkina,M I Butomo,A I Metlinskaya,A R Almukhambedova,S Serikbolkyzy,E Yu Gubareva,S V Kozlov,A A Obukhova,K K Azaryan,E A Yausheva,E Yu Obolentseva,Abdirashit Maripov ,А К Абдрахманова ,D V Soloveva ,O Yu Barysheva ,Н В Заречнова ,Е В Королева ,Yu V Omarova ,А Ч Акунов ,Г В Щербакова ,А О Конради ,D.n Protsenko ,Е В Пахомова ,И М Сухомлинова ,D S Polyakov ,Л Д Петров ,К Е Егорова ,E I Tarlovskaya ,S V Malchikova ,Melis Duishobaev ,М И Колядич ,И И Шапошник ,Yu D Rabik ,В А Павлова ,O Yu Dolgikh ,I V Demko ,В В Вустина ,N А Magdeeva ,Ч К Кулчороева ,А С Кузнецова ,Н А Раков ,И Г Бакулин ,H G Hayrapetyan ,Akhmetzhan Sugraliyev ,А А Туличев ,А В Жарков ,М В Болдина ,Е A Verbitskaya ,А В Апаркина ,A A Ledyaeva ,А Р Вайсберг ,С С Пластинина ,А П Ребров ,И С Фоминова ,А П Бабин ,Ф Н Мурадова ,М С Торгунакова ,E Yu Ashina ,Т Yu Kuznetsova ,В И Леванкова ,S N Tereshchenko ,H G Avoyan ,К V Protasov ,И Г Починка ,N A Prokofieva ,K Yu Shishkov ,D V Polyakov ,А И Демченко ,I Yu Fomina ,О Р Арусланова ,Р А Башкинов ,Н А Кароли ,A A Zateishchikova ,Н В Киселева ,М К Алиева ,И А Фролова ,А М Битиева ,Yu S Kalinina ,Н М Селезнева ,А М Буду ,М П Коновал ,Н Д Уланова ,V I Majseenko ,А Т Турсунова ,О В Ковалишена ,В В Генкель ,A N Kulikov ,А В Евзерихина ,Olga Shevchenko ,D Yu Ruzanov ,А С Батчаева ,И В Губарева ,Е В Колмакова ,Д Д Варламова ,Ekaterina Shishkina ,Yu V Titojkina ,А Н Рахимов ,А Г Сушилова ,Е В Казымова ,Victoria Brazhnik ,А А Симонов ,Н В Бакулина ,N Yu Kurchugina ,Н А Омурзакова ,D R Tagaeva ,В В Скачкова ,Д А Трофимов ,К В Треногина ,Т И Чудиновских ,В В Гомонова ,Г М Дабылова ,А Yu Kraposhina ,О В Фатенков ,Н А Камардина ,Yu D Zimina ,Л А Балыкова ,М М Петрова ,Н А Розанова ,A Sh Sarybaev ,Е С Некаева ,D Yu Konstantinov ,O Yu Chizhova ,О Е Вилкова ,E V Makarova ,М Х Карсиев ,Г Т Аймаханова ,Л В Куренкова ,С М Цвингер ,Samvel A Avetisyan ,М В Казаковцева ,Б Б Огурлиева ,I U Bikhteyev ,А В Климова ,Н М Никитина ,Д С Токмин ,Irina A Soloveva ,Е А Винникова ,Yu M Lopatin ,К В Мазалов ,В В Цома ,Е В Пономаренко ,Giller Db ,Т В Куприна ,Ш О Оспанова ,Т И Батлук ,K R Vagapova ,А А Марусина ,D S Кaskaeva ,O V Khlynova ,М А Трубникова ,Е А Константинова ,E S Melnikov ,Н А Бородулина ,О В Кондрякова ,Umida Kamilova ,А И Чесникова ,Л Л Попова ,С Е Нифонтов ,Elena V Grigorieva ,Meerim Cholponbaeva ,А Н Ермилова ,Е И Горшенина ,Е П Тихонова ,Д С Евдокимов ,Nadira Kushubakova ,А А Толмачева ,Г А Быкова ,Olga Fedorishina ,М В Брагин ,O Yu Badina ,N Yu Grigoryeva ,Yu N Belenkov ,И В Фомин ,Artem A Potanin ,И А Каретников ,Н Н Везикова ,Д А Клименко ,Д С Скуридин ,Elena A Galova ,N.v Lareva ,S Yu Ivanova ,Jainagul Kerimbekova ,Dinara Aalyevna Aiypova ,T Y Kuzmina ,А С Макарова ,Н Б Моисеенко ,А М Караченова ,А А Одегова ,M V Ilina ,К Ф Касымова ,S A Sayganov ,S Yu Shcherbakov

doi:10.15829/1560-4071-2022-5042

Abstract

Aim. To study the lipid profile in hospitalized patients with coronavirus disease 2019 (COVID-19) depending on the outcome of its acute phase according to the AKTIV international registry.Material and methods. The AKTIV registry included men and women over 18 years of age with a diagnosis of COVID-19, who were treated in a hospital. A total of 9364 patients were included in the registry, of which 623 patients were analyzed for levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C) and triglycerides on days 1-2 of hospitalization. The level of high-density lipoprotein cholesterol (HDL-C) was calculated using the Friedewald equation.Results. We found that a decrease in LDL-C level was significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. This pattern persisted in both univariate and multivariate analyses. LDL-C levels in the final multivariate model had a significant relationship with the prognosis (an increase in the death risk by 1,7 times with a decrease per 1 mmol/l). In addition, we found that the survival of patients with an indicator level of <2,45 mmol/l is significantly worse than in patients with an LDL-C level ≥2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<2,45 mmol/l. All patients with high LDL-C ((≥4,9 mmol/l) survived, while among patients with low LDL-C (<1,4 mmol/l), mortality was 13,04%, which was significantly higher than in patients with LDL-C ≥1,4 mmol/l (6,32%, p=0,047).Conclusion. A decrease in LDL-C in the acute period is significantly associated with an unfavorable prognosis for hospitalized patients with COVID-19. Determination of LDL-C can be included in the examination program for patients with COVID-19. However, the predictive value of this parameter requires further study in prospective clinical studies.

Full Text